Cancer-derived cholesterol sulfate is a key mediator to prevent tumor infiltration by effector T cells

Effective tumor immunotherapy requires physical contact of T cells with cancer cells. However, tumors often constitute a specialized microenvironment that excludes T cells from the vicinity of cancer cells, and its underlying mechanisms are still poorly understood. DOCK2 is a Rac activator critical...

Descripción completa

Detalles Bibliográficos
Autores principales: Tatsuguchi, Takaaki, Uruno, Takehito, Sugiura, Yuki, Sakata, Daiji, Izumi, Yoshihiro, Sakurai, Tetsuya, Hattori, Yuko, Oki, Eiji, Kubota, Naoto, Nishimoto, Koshiro, Oyama, Masafumi, Kunimura, Kazufumi, Ohki, Takuto, Bamba, Takeshi, Tahara, Hideaki, Sakamoto, Michiie, Nakamura, Masafumi, Suematsu, Makoto, Fukui, Yoshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020568/
https://www.ncbi.nlm.nih.gov/pubmed/35094065
http://dx.doi.org/10.1093/intimm/dxac002

Ejemplares similares

Ejemplares similares