Recent developments in the structural characterisation of the IR and IGF1R: implications for the design of IR–IGF1R hybrid receptor modulators

The insulin receptor (IR) and insulin-like growth factor 1 receptor (IGF1R) are dimeric disulfide-linked receptor tyrosine kinases, whose actions regulate metabolic and mitogenic signalling pathways inside the cell. It is well documented that in tissues co-expressing the IR and IGF1R, their respecti...

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Detalles Bibliográficos
Autores principales: Turvey, Samuel J., McPhillie, Martin J., Kearney, Mark T., Muench, Stephen P., Simmons, Katie J., Fishwick, Colin W. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020618/
https://www.ncbi.nlm.nih.gov/pubmed/35647546
http://dx.doi.org/10.1039/d1md00300c

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