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Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke
Brain imaging is essential to the clinical management of patients with ischemic stroke. Timely and accessible neuroimaging, however, can be limited in clinical stroke pathways. Here, portable magnetic resonance imaging (pMRI) acquired at very low magnetic field strength (0.064 T) is used to obtain a...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020661/ https://www.ncbi.nlm.nih.gov/pubmed/35442729 http://dx.doi.org/10.1126/sciadv.abm3952 |
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author | Yuen, Matthew M. Prabhat, Anjali M. Mazurek, Mercy H. Chavva, Isha R. Crawford, Anna Cahn, Bradley A. Beekman, Rachel Kim, Jennifer A. Gobeske, Kevin T. Petersen, Nils H. Falcone, Guido J. Gilmore, Emily J. Hwang, David Y. Jasne, Adam S. Amin, Hardik Sharma, Richa Matouk, Charles Ward, Adrienne Schindler, Joseph Sansing, Lauren de Havenon, Adam Aydin, Ani Wira, Charles Sze, Gordon Rosen, Matthew S. Kimberly, W. Taylor Sheth, Kevin N. |
author_facet | Yuen, Matthew M. Prabhat, Anjali M. Mazurek, Mercy H. Chavva, Isha R. Crawford, Anna Cahn, Bradley A. Beekman, Rachel Kim, Jennifer A. Gobeske, Kevin T. Petersen, Nils H. Falcone, Guido J. Gilmore, Emily J. Hwang, David Y. Jasne, Adam S. Amin, Hardik Sharma, Richa Matouk, Charles Ward, Adrienne Schindler, Joseph Sansing, Lauren de Havenon, Adam Aydin, Ani Wira, Charles Sze, Gordon Rosen, Matthew S. Kimberly, W. Taylor Sheth, Kevin N. |
author_sort | Yuen, Matthew M. |
collection | PubMed |
description | Brain imaging is essential to the clinical management of patients with ischemic stroke. Timely and accessible neuroimaging, however, can be limited in clinical stroke pathways. Here, portable magnetic resonance imaging (pMRI) acquired at very low magnetic field strength (0.064 T) is used to obtain actionable bedside neuroimaging for 50 confirmed patients with ischemic stroke. Low-field pMRI detected infarcts in 45 (90%) patients across cortical, subcortical, and cerebellar structures. Lesions as small as 4 mm were captured. Infarcts appeared as hyperintense regions on T2-weighted, fluid-attenuated inversion recovery and diffusion-weighted imaging sequences. Stroke volume measurements were consistent across pMRI sequences and between low-field pMRI and conventional high-field MRI studies. Low-field pMRI stroke volumes significantly correlated with stroke severity and functional outcome at discharge. These results validate the use of low-field pMRI to obtain clinically useful imaging of stroke, setting the stage for use in resource-limited environments. |
format | Online Article Text |
id | pubmed-9020661 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-90206612022-05-03 Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke Yuen, Matthew M. Prabhat, Anjali M. Mazurek, Mercy H. Chavva, Isha R. Crawford, Anna Cahn, Bradley A. Beekman, Rachel Kim, Jennifer A. Gobeske, Kevin T. Petersen, Nils H. Falcone, Guido J. Gilmore, Emily J. Hwang, David Y. Jasne, Adam S. Amin, Hardik Sharma, Richa Matouk, Charles Ward, Adrienne Schindler, Joseph Sansing, Lauren de Havenon, Adam Aydin, Ani Wira, Charles Sze, Gordon Rosen, Matthew S. Kimberly, W. Taylor Sheth, Kevin N. Sci Adv Physical and Materials Sciences Brain imaging is essential to the clinical management of patients with ischemic stroke. Timely and accessible neuroimaging, however, can be limited in clinical stroke pathways. Here, portable magnetic resonance imaging (pMRI) acquired at very low magnetic field strength (0.064 T) is used to obtain actionable bedside neuroimaging for 50 confirmed patients with ischemic stroke. Low-field pMRI detected infarcts in 45 (90%) patients across cortical, subcortical, and cerebellar structures. Lesions as small as 4 mm were captured. Infarcts appeared as hyperintense regions on T2-weighted, fluid-attenuated inversion recovery and diffusion-weighted imaging sequences. Stroke volume measurements were consistent across pMRI sequences and between low-field pMRI and conventional high-field MRI studies. Low-field pMRI stroke volumes significantly correlated with stroke severity and functional outcome at discharge. These results validate the use of low-field pMRI to obtain clinically useful imaging of stroke, setting the stage for use in resource-limited environments. American Association for the Advancement of Science 2022-04-20 /pmc/articles/PMC9020661/ /pubmed/35442729 http://dx.doi.org/10.1126/sciadv.abm3952 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Physical and Materials Sciences Yuen, Matthew M. Prabhat, Anjali M. Mazurek, Mercy H. Chavva, Isha R. Crawford, Anna Cahn, Bradley A. Beekman, Rachel Kim, Jennifer A. Gobeske, Kevin T. Petersen, Nils H. Falcone, Guido J. Gilmore, Emily J. Hwang, David Y. Jasne, Adam S. Amin, Hardik Sharma, Richa Matouk, Charles Ward, Adrienne Schindler, Joseph Sansing, Lauren de Havenon, Adam Aydin, Ani Wira, Charles Sze, Gordon Rosen, Matthew S. Kimberly, W. Taylor Sheth, Kevin N. Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke |
title | Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke |
title_full | Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke |
title_fullStr | Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke |
title_full_unstemmed | Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke |
title_short | Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke |
title_sort | portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke |
topic | Physical and Materials Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020661/ https://www.ncbi.nlm.nih.gov/pubmed/35442729 http://dx.doi.org/10.1126/sciadv.abm3952 |
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