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Multiscale affinity maturation simulations to elicit broadly neutralizing antibodies against HIV

The design of vaccines against highly mutable pathogens, such as HIV and influenza, requires a detailed understanding of how the adaptive immune system responds to encountering multiple variant antigens (Ags). Here, we describe a multiscale model of B cell receptor (BCR) affinity maturation that emp...

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Detalles Bibliográficos
Autores principales:	Conti, Simone, Ovchinnikov, Victor, Faris, Jonathan G., Chakraborty, Arup K., Karplus, Martin, Sprenger, Kayla G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020693/ https://www.ncbi.nlm.nih.gov/pubmed/35442968 http://dx.doi.org/10.1371/journal.pcbi.1009391

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