Cargando…

Multiscale affinity maturation simulations to elicit broadly neutralizing antibodies against HIV

The design of vaccines against highly mutable pathogens, such as HIV and influenza, requires a detailed understanding of how the adaptive immune system responds to encountering multiple variant antigens (Ags). Here, we describe a multiscale model of B cell receptor (BCR) affinity maturation that emp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Conti, Simone, Ovchinnikov, Victor, Faris, Jonathan G., Chakraborty, Arup K., Karplus, Martin, Sprenger, Kayla G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020693/ https://www.ncbi.nlm.nih.gov/pubmed/35442968 http://dx.doi.org/10.1371/journal.pcbi.1009391

Ejemplares similares

Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies
por: Ovchinnikov, Victor, et al.
Publicado: (2018)

On the Rapid Calculation of Binding Affinities for Antigen and Antibody Design and Affinity Maturation Simulations
por: Conti, Simone, et al.
Publicado: (2022)

A Coarse-Grained Model of Affinity Maturation Indicates the Importance of B-Cell Receptor Avidity in Epitope Subdominance
por: Ovchinnikov, Victor, et al.
Publicado: (2022)

Free Energy Simulations of Receptor-Binding Domain Opening of the SARS-CoV-2 Spike Indicate a Barrierless Transition with Slow Conformational Motions
por: Ovchinnikov, Victor, et al.
Publicado: (2023)

Key mutations stabilize antigen-binding conformation during affinity maturation of a broadly neutralizing influenza antibody lineage
por: Xu, Huafeng, et al.
Publicado: (2015)

Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows
por: Sok, Devin, et al.
Publicado: (2017)

Designer antigens for elicitation of broadly neutralizing antibodies against HIV
por: Kok, Tuckweng, et al.
Publicado: (2014)

Development of an anti-HIV vaccine eliciting broadly neutralizing antibodies
por: Ahmed, Yousuf, et al.
Publicado: (2017)

Computational Prediction of Broadly Neutralizing HIV-1 Antibody Epitopes from Neutralization Activity Data
por: Ferguson, Andrew L., et al.
Publicado: (2013)

The Effects of Framework Mutations at the Variable Domain Interface on Antibody Affinity Maturation in an HIV-1 Broadly Neutralizing Antibody Lineage
por: Zhou, Jeffrey O., et al.
Publicado: (2020)

The Antibody Germline/Maturation Hypothesis, Elicitation of Broadly Neutralizing Antibodies Against HIV-1 and Cord Blood IgM Repertoires
por: Prabakaran, Ponraj, et al.
Publicado: (2014)

The low spike density of HIV may have evolved because of the effects of T helper cell depletion on affinity maturation
por: Amitai, Assaf, et al.
Publicado: (2018)

Corrigendum: The Effects of Framework Mutations at the Variable Domain Interface on Antibody Affinity Maturation in an HIV-1 Broadly Neutralizing Antibody Lineage
por: Zhou, Jeffrey O., et al.
Publicado: (2020)

Potent and broad neutralization of HIV-1 by a llama antibody elicited by immunization
por: McCoy, Laura E., et al.
Publicado: (2012)

Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells
por: Huang, Deli, et al.
Publicado: (2020)

Delta breakthrough infections elicit potent, broad and durable neutralizing antibody responses
por: Walls, Alexandra C., et al.
Publicado: (2021)

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies
por: Briney, Bryan, et al.
Publicado: (2016)

Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies
por: Phillips, Angela M, et al.
Publicado: (2021)

Eliciting broadly neutralizing antibodies against HIV-1 that target gp41 MPER
por: Han, D, et al.
Publicado: (2012)

Fc-Based Recombinant Henipavirus Vaccines Elicit Broad Neutralizing Antibody Responses in Mice
por: Li, Yaohui, et al.
Publicado: (2020)

HIV Coinfection Provides Insights for the Design of Vaccine Cocktails to Elicit Broadly Neutralizing Antibodies
por: Sheward, Daniel J., et al.
Publicado: (2022)

Omicron infection elicits a broad neutralizing response in hospitalized patients with COVID-19
por: McNally, Elizabeth M.
Publicado: (2022)

Tertiary and quaternary structural basis of oxygen affinity in human hemoglobin as revealed by multiscale simulations
por: Bringas, Mauro, et al.
Publicado: (2017)

P04-07. Guiding the immune system through complex maturation pathways: a novel multi-immunogen approach for elicitation of broadly neutralizing antibodies
por: Xiao, X, et al.
Publicado: (2009)

Retraction: eliciting broadly neutralizing antibodies against HIV-1 that target gp41 MPER
por: Han, D, et al.
Publicado: (2014)

Author Correction: Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells
por: Huang, Deli, et al.
Publicado: (2020)

Manipulating the selection forces during affinity maturation to generate cross-reactive HIV antibodies
por: Wang, Shenshen, et al.
Publicado: (2015)

SARS-CoV-2 breakthrough infections elicit potent, broad, and durable neutralizing antibody responses
por: Walls, Alexandra C., et al.
Publicado: (2022)

Structural insights into broadly neutralizing antibodies elicited by hybrid immunity against SARS-CoV-2
por: Luo, Mengxiao, et al.
Publicado: (2023)

Broad and potent neutralizing antibodies are elicited in vaccinated individuals following Delta/BA.1 breakthrough infection
por: Seow, Jeffrey, et al.
Publicado: (2023)

Complexes of Neutralizing and Non-Neutralizing Affinity Matured Fabs with a Mimetic of the Internal Trimeric Coiled-Coil of HIV-1 gp41
por: Gustchina, Elena, et al.
Publicado: (2013)

Multiscale modelling and simulation
por: Attinger, Sabine, et al.
Publicado: (2004)

Multiscale simulations of viruses
por: Yu, Alvin, et al.
Publicado: (2022)

Performance of distributed multiscale simulations
por: Borgdorff, J., et al.
Publicado: (2014)

Estimation of the breadth of CD4bs targeting HIV antibodies by molecular modeling and machine learning
por: Conti, Simone, et al.
Publicado: (2019)

The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies
por: Sok, Devin, et al.
Publicado: (2013)

Affinity maturation pathway of an anti-MPER neutralizing mAb, CAP206-CH12
por: Tumba, NL, et al.
Publicado: (2012)

Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation
por: Hurlburt, Nicholas K., et al.
Publicado: (2020)

Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation
por: Hurlburt, Nicholas K., et al.
Publicado: (2020)

Inactivated vaccine-elicited potent antibodies can broadly neutralize SARS-CoV-2 circulating variants
por: Liu, Yubin, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_fg11irmg9l6dt5ltgnd3fiolih