Novel aerosol treatment of airway hyper-reactivity and inflammation in a murine model of asthma with a soluble epoxide hydrolase inhibitor

Asthma currently affects more than 339 million people worldwide. In the present preliminary study, we examined the efficacy of a new, inhalable soluble epoxide hydrolase inhibitor (sEHI), 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), to attenuate airway inflammation, mucin secr...

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Detalles Bibliográficos
Autores principales: Zhang, Chuanzhen, Li, Wei, Li, Xiyuan, Wan, Debin, Mack, Savannah, Zhang, Jingjing, Wagner, Karen, Wang, Chang, Tan, Bowen, Chen, Jason, Wu, Ching-Wen, Tsuji, Kaori, Takeuchi, Minoru, Chen, Ziping, Hammock, Bruce D., Pinkerton, Kent E., Yang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020733/
https://www.ncbi.nlm.nih.gov/pubmed/35443010
http://dx.doi.org/10.1371/journal.pone.0266608

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