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Efficacy and specificity of inhibitors of BCL-2 family protein interactions assessed by affinity measurements in live cells

Cytoplasmic and membrane-bound BCL-2 family proteins regulate apoptosis, a form of programmed cell death, via dozens of binary protein interactions confounding measurement of the effects of inhibitors in live cells. In cancer, apoptosis is frequently dysregulated, and cell survival depends on antiap...

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Detalles Bibliográficos
Autores principales:	Osterlund, Elizabeth J., Hirmiz, Nehad, Pemberton, James M., Nougarède, Adrien, Liu, Qian, Leber, Brian, Fang, Qiyin, Andrews, David W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020777/ https://www.ncbi.nlm.nih.gov/pubmed/35442739 http://dx.doi.org/10.1126/sciadv.abm7375

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