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Blood-brain barrier–penetrating single CRISPR-Cas9 nanocapsules for effective and safe glioblastoma gene therapy

We designed a unique nanocapsule for efficient single CRISPR-Cas9 capsuling, noninvasive brain delivery and tumor cell targeting, demonstrating an effective and safe strategy for glioblastoma gene therapy. Our CRISPR-Cas9 nanocapsules can be simply fabricated by encapsulating the single Cas9/sgRNA c...

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Detalles Bibliográficos
Autores principales:	Zou, Yan, Sun, Xinhong, Yang, Qingshan, Zheng, Meng, Shimoni, Olga, Ruan, Weimin, Wang, Yibin, Zhang, Dongya, Yin, Jinlong, Huang, Xiangang, Tao, Wei, Park, Jong Bae, Liang, Xing-Jie, Leong, Kam W., Shi, Bingyang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2022
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020780/ https://www.ncbi.nlm.nih.gov/pubmed/35442747 http://dx.doi.org/10.1126/sciadv.abm8011

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