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Evaluation of the Clinical Effectiveness of Oseltamivir for Influenza Treatment in Children

Objective: To estimate the clinical effectiveness of oseltamivir in children with different subtypes of influenza virus infection. Methods: A total of 998 children with acute respiratory infection were enrolled from January to March 2018, and were divided into influenza A, influenza B, influenza A +...

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Autores principales: Qin, Jianru, Lin, Jilei, Zhang, Xiangfei, Yuan, Shuhua, Zhang, Chiyu, Yin, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020783/
https://www.ncbi.nlm.nih.gov/pubmed/35462914
http://dx.doi.org/10.3389/fphar.2022.849545
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author Qin, Jianru
Lin, Jilei
Zhang, Xiangfei
Yuan, Shuhua
Zhang, Chiyu
Yin, Yong
author_facet Qin, Jianru
Lin, Jilei
Zhang, Xiangfei
Yuan, Shuhua
Zhang, Chiyu
Yin, Yong
author_sort Qin, Jianru
collection PubMed
description Objective: To estimate the clinical effectiveness of oseltamivir in children with different subtypes of influenza virus infection. Methods: A total of 998 children with acute respiratory infection were enrolled from January to March 2018, and were divided into influenza A, influenza B, influenza A + B, and non-influenza infection (IV-negative) groups. Influenza-like symptoms and duration of fever were evaluated and compared between oseltamivir-treated and non-treated groups. Results: There were no significant differences in the reduction in total febrile period and duration of fever from the onset of therapy between the oseltamivir treated and non-treated children infected with influenza A (p = 0.6885 for total febrile period and 0.7904 for the duration of fever from the onset of treatment), influenza B (p = 0.1462 and 0.1966), influenza A + B (p = 0.5568 and 0.9320), and IV-negative (p = 0.7631 and 0.4655). The duration of fever in children received oseltamivir therapy within 48 h was not significantly shorter than that beyond 48 h (p > 0.05). Additionally, percentages and severities of influenza-like symptoms, including headache, myalgia, fatigue, bellyache, vomiting, diarrhea, sore throat, cough, and coryza were not decreased and alleviated after treatment of oseltamivir. Conclusion: Oseltamivir treatment does not significantly shorten the duration of fever, nor does it significantly relieve influenza-like symptoms in children with infection of influenza.
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spelling pubmed-90207832022-04-21 Evaluation of the Clinical Effectiveness of Oseltamivir for Influenza Treatment in Children Qin, Jianru Lin, Jilei Zhang, Xiangfei Yuan, Shuhua Zhang, Chiyu Yin, Yong Front Pharmacol Pharmacology Objective: To estimate the clinical effectiveness of oseltamivir in children with different subtypes of influenza virus infection. Methods: A total of 998 children with acute respiratory infection were enrolled from January to March 2018, and were divided into influenza A, influenza B, influenza A + B, and non-influenza infection (IV-negative) groups. Influenza-like symptoms and duration of fever were evaluated and compared between oseltamivir-treated and non-treated groups. Results: There were no significant differences in the reduction in total febrile period and duration of fever from the onset of therapy between the oseltamivir treated and non-treated children infected with influenza A (p = 0.6885 for total febrile period and 0.7904 for the duration of fever from the onset of treatment), influenza B (p = 0.1462 and 0.1966), influenza A + B (p = 0.5568 and 0.9320), and IV-negative (p = 0.7631 and 0.4655). The duration of fever in children received oseltamivir therapy within 48 h was not significantly shorter than that beyond 48 h (p > 0.05). Additionally, percentages and severities of influenza-like symptoms, including headache, myalgia, fatigue, bellyache, vomiting, diarrhea, sore throat, cough, and coryza were not decreased and alleviated after treatment of oseltamivir. Conclusion: Oseltamivir treatment does not significantly shorten the duration of fever, nor does it significantly relieve influenza-like symptoms in children with infection of influenza. Frontiers Media S.A. 2022-04-06 /pmc/articles/PMC9020783/ /pubmed/35462914 http://dx.doi.org/10.3389/fphar.2022.849545 Text en Copyright © 2022 Qin, Lin, Zhang, Yuan, Zhang and Yin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Qin, Jianru
Lin, Jilei
Zhang, Xiangfei
Yuan, Shuhua
Zhang, Chiyu
Yin, Yong
Evaluation of the Clinical Effectiveness of Oseltamivir for Influenza Treatment in Children
title Evaluation of the Clinical Effectiveness of Oseltamivir for Influenza Treatment in Children
title_full Evaluation of the Clinical Effectiveness of Oseltamivir for Influenza Treatment in Children
title_fullStr Evaluation of the Clinical Effectiveness of Oseltamivir for Influenza Treatment in Children
title_full_unstemmed Evaluation of the Clinical Effectiveness of Oseltamivir for Influenza Treatment in Children
title_short Evaluation of the Clinical Effectiveness of Oseltamivir for Influenza Treatment in Children
title_sort evaluation of the clinical effectiveness of oseltamivir for influenza treatment in children
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020783/
https://www.ncbi.nlm.nih.gov/pubmed/35462914
http://dx.doi.org/10.3389/fphar.2022.849545
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