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Evaluation of the Clinical Effectiveness of Oseltamivir for Influenza Treatment in Children
Objective: To estimate the clinical effectiveness of oseltamivir in children with different subtypes of influenza virus infection. Methods: A total of 998 children with acute respiratory infection were enrolled from January to March 2018, and were divided into influenza A, influenza B, influenza A +...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020783/ https://www.ncbi.nlm.nih.gov/pubmed/35462914 http://dx.doi.org/10.3389/fphar.2022.849545 |
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author | Qin, Jianru Lin, Jilei Zhang, Xiangfei Yuan, Shuhua Zhang, Chiyu Yin, Yong |
author_facet | Qin, Jianru Lin, Jilei Zhang, Xiangfei Yuan, Shuhua Zhang, Chiyu Yin, Yong |
author_sort | Qin, Jianru |
collection | PubMed |
description | Objective: To estimate the clinical effectiveness of oseltamivir in children with different subtypes of influenza virus infection. Methods: A total of 998 children with acute respiratory infection were enrolled from January to March 2018, and were divided into influenza A, influenza B, influenza A + B, and non-influenza infection (IV-negative) groups. Influenza-like symptoms and duration of fever were evaluated and compared between oseltamivir-treated and non-treated groups. Results: There were no significant differences in the reduction in total febrile period and duration of fever from the onset of therapy between the oseltamivir treated and non-treated children infected with influenza A (p = 0.6885 for total febrile period and 0.7904 for the duration of fever from the onset of treatment), influenza B (p = 0.1462 and 0.1966), influenza A + B (p = 0.5568 and 0.9320), and IV-negative (p = 0.7631 and 0.4655). The duration of fever in children received oseltamivir therapy within 48 h was not significantly shorter than that beyond 48 h (p > 0.05). Additionally, percentages and severities of influenza-like symptoms, including headache, myalgia, fatigue, bellyache, vomiting, diarrhea, sore throat, cough, and coryza were not decreased and alleviated after treatment of oseltamivir. Conclusion: Oseltamivir treatment does not significantly shorten the duration of fever, nor does it significantly relieve influenza-like symptoms in children with infection of influenza. |
format | Online Article Text |
id | pubmed-9020783 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90207832022-04-21 Evaluation of the Clinical Effectiveness of Oseltamivir for Influenza Treatment in Children Qin, Jianru Lin, Jilei Zhang, Xiangfei Yuan, Shuhua Zhang, Chiyu Yin, Yong Front Pharmacol Pharmacology Objective: To estimate the clinical effectiveness of oseltamivir in children with different subtypes of influenza virus infection. Methods: A total of 998 children with acute respiratory infection were enrolled from January to March 2018, and were divided into influenza A, influenza B, influenza A + B, and non-influenza infection (IV-negative) groups. Influenza-like symptoms and duration of fever were evaluated and compared between oseltamivir-treated and non-treated groups. Results: There were no significant differences in the reduction in total febrile period and duration of fever from the onset of therapy between the oseltamivir treated and non-treated children infected with influenza A (p = 0.6885 for total febrile period and 0.7904 for the duration of fever from the onset of treatment), influenza B (p = 0.1462 and 0.1966), influenza A + B (p = 0.5568 and 0.9320), and IV-negative (p = 0.7631 and 0.4655). The duration of fever in children received oseltamivir therapy within 48 h was not significantly shorter than that beyond 48 h (p > 0.05). Additionally, percentages and severities of influenza-like symptoms, including headache, myalgia, fatigue, bellyache, vomiting, diarrhea, sore throat, cough, and coryza were not decreased and alleviated after treatment of oseltamivir. Conclusion: Oseltamivir treatment does not significantly shorten the duration of fever, nor does it significantly relieve influenza-like symptoms in children with infection of influenza. Frontiers Media S.A. 2022-04-06 /pmc/articles/PMC9020783/ /pubmed/35462914 http://dx.doi.org/10.3389/fphar.2022.849545 Text en Copyright © 2022 Qin, Lin, Zhang, Yuan, Zhang and Yin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Qin, Jianru Lin, Jilei Zhang, Xiangfei Yuan, Shuhua Zhang, Chiyu Yin, Yong Evaluation of the Clinical Effectiveness of Oseltamivir for Influenza Treatment in Children |
title | Evaluation of the Clinical Effectiveness of Oseltamivir for Influenza Treatment in Children |
title_full | Evaluation of the Clinical Effectiveness of Oseltamivir for Influenza Treatment in Children |
title_fullStr | Evaluation of the Clinical Effectiveness of Oseltamivir for Influenza Treatment in Children |
title_full_unstemmed | Evaluation of the Clinical Effectiveness of Oseltamivir for Influenza Treatment in Children |
title_short | Evaluation of the Clinical Effectiveness of Oseltamivir for Influenza Treatment in Children |
title_sort | evaluation of the clinical effectiveness of oseltamivir for influenza treatment in children |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020783/ https://www.ncbi.nlm.nih.gov/pubmed/35462914 http://dx.doi.org/10.3389/fphar.2022.849545 |
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