Hemophagocytic Lymphohistiocytosis: A Rare Cause of Pyrexia of Unknown Origin

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome due to excessive immune activation leading to hyperinflammation. It may be familial due to mutations in immune regulatory genes, especially genetic defects of lymphocyte toxicity. The sporadic cases are triggered by infections (...

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Detalles Bibliográficos
Autores principales: Khan, Salman, Naim, Fahad, Ullah, Hameed, Niaz, Falak, Bilal, Muhammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020787/
https://www.ncbi.nlm.nih.gov/pubmed/35475043
http://dx.doi.org/10.7759/cureus.23368
Descripción
Sumario:Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome due to excessive immune activation leading to hyperinflammation. It may be familial due to mutations in immune regulatory genes, especially genetic defects of lymphocyte toxicity. The sporadic cases are triggered by infections (mostly viral), malignancies, and autoimmune diseases. Herewith we report the case of a 20-year-old male with febrile illness who was ultimately diagnosed with HLH.

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