Hemophagocytic Lymphohistiocytosis: A Rare Cause of Pyrexia of Unknown Origin

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome due to excessive immune activation leading to hyperinflammation. It may be familial due to mutations in immune regulatory genes, especially genetic defects of lymphocyte toxicity. The sporadic cases are triggered by infections (...

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Detalles Bibliográficos
Autores principales: Khan, Salman, Naim, Fahad, Ullah, Hameed, Niaz, Falak, Bilal, Muhammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020787/
https://www.ncbi.nlm.nih.gov/pubmed/35475043
http://dx.doi.org/10.7759/cureus.23368
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author Khan, Salman
Naim, Fahad
Ullah, Hameed
Niaz, Falak
Bilal, Muhammad
author_facet Khan, Salman
Naim, Fahad
Ullah, Hameed
Niaz, Falak
Bilal, Muhammad
author_sort Khan, Salman
collection PubMed
description Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome due to excessive immune activation leading to hyperinflammation. It may be familial due to mutations in immune regulatory genes, especially genetic defects of lymphocyte toxicity. The sporadic cases are triggered by infections (mostly viral), malignancies, and autoimmune diseases. Herewith we report the case of a 20-year-old male with febrile illness who was ultimately diagnosed with HLH.
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spelling pubmed-90207872022-04-25 Hemophagocytic Lymphohistiocytosis: A Rare Cause of Pyrexia of Unknown Origin Khan, Salman Naim, Fahad Ullah, Hameed Niaz, Falak Bilal, Muhammad Cureus Internal Medicine Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome due to excessive immune activation leading to hyperinflammation. It may be familial due to mutations in immune regulatory genes, especially genetic defects of lymphocyte toxicity. The sporadic cases are triggered by infections (mostly viral), malignancies, and autoimmune diseases. Herewith we report the case of a 20-year-old male with febrile illness who was ultimately diagnosed with HLH. Cureus 2022-03-21 /pmc/articles/PMC9020787/ /pubmed/35475043 http://dx.doi.org/10.7759/cureus.23368 Text en Copyright © 2022, Khan et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Khan, Salman
Naim, Fahad
Ullah, Hameed
Niaz, Falak
Bilal, Muhammad
Hemophagocytic Lymphohistiocytosis: A Rare Cause of Pyrexia of Unknown Origin
title Hemophagocytic Lymphohistiocytosis: A Rare Cause of Pyrexia of Unknown Origin
title_full Hemophagocytic Lymphohistiocytosis: A Rare Cause of Pyrexia of Unknown Origin
title_fullStr Hemophagocytic Lymphohistiocytosis: A Rare Cause of Pyrexia of Unknown Origin
title_full_unstemmed Hemophagocytic Lymphohistiocytosis: A Rare Cause of Pyrexia of Unknown Origin
title_short Hemophagocytic Lymphohistiocytosis: A Rare Cause of Pyrexia of Unknown Origin
title_sort hemophagocytic lymphohistiocytosis: a rare cause of pyrexia of unknown origin
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020787/
https://www.ncbi.nlm.nih.gov/pubmed/35475043
http://dx.doi.org/10.7759/cureus.23368
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AT naimfahad hemophagocyticlymphohistiocytosisararecauseofpyrexiaofunknownorigin
AT ullahhameed hemophagocyticlymphohistiocytosisararecauseofpyrexiaofunknownorigin
AT niazfalak hemophagocyticlymphohistiocytosisararecauseofpyrexiaofunknownorigin
AT bilalmuhammad hemophagocyticlymphohistiocytosisararecauseofpyrexiaofunknownorigin

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