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Activity in perirhinal and entorhinal cortex predicts perceived visual similarities among category exemplars with highest precision

Vision neuroscience has made great strides in understanding the hierarchical organization of object representations along the ventral visual stream (VVS). How VVS representations capture fine-grained visual similarities between objects that observers subjectively perceive has received limited examin...

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Autores principales: Ferko, Kayla M, Blumenthal, Anna, Martin, Chris B, Proklova, Daria, Minos, Alexander N, Saksida, Lisa M, Bussey, Timothy J, Khan, Ali R, Köhler, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020819/
https://www.ncbi.nlm.nih.gov/pubmed/35311645
http://dx.doi.org/10.7554/eLife.66884
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author Ferko, Kayla M
Blumenthal, Anna
Martin, Chris B
Proklova, Daria
Minos, Alexander N
Saksida, Lisa M
Bussey, Timothy J
Khan, Ali R
Köhler, Stefan
author_facet Ferko, Kayla M
Blumenthal, Anna
Martin, Chris B
Proklova, Daria
Minos, Alexander N
Saksida, Lisa M
Bussey, Timothy J
Khan, Ali R
Köhler, Stefan
author_sort Ferko, Kayla M
collection PubMed
description Vision neuroscience has made great strides in understanding the hierarchical organization of object representations along the ventral visual stream (VVS). How VVS representations capture fine-grained visual similarities between objects that observers subjectively perceive has received limited examination so far. In the current study, we addressed this question by focussing on perceived visual similarities among subordinate exemplars of real-world categories. We hypothesized that these perceived similarities are reflected with highest fidelity in neural activity patterns downstream from inferotemporal regions, namely in perirhinal (PrC) and anterolateral entorhinal cortex (alErC) in the medial temporal lobe. To address this issue with functional magnetic resonance imaging (fMRI), we administered a modified 1-back task that required discrimination between category exemplars as well as categorization. Further, we obtained observer-specific ratings of perceived visual similarities, which predicted behavioural discrimination performance during scanning. As anticipated, we found that activity patterns in PrC and alErC predicted the structure of perceived visual similarity relationships among category exemplars, including its observer-specific component, with higher precision than any other VVS region. Our findings provide new evidence that subjective aspects of object perception that rely on fine-grained visual differentiation are reflected with highest fidelity in the medial temporal lobe.
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spelling pubmed-90208192022-04-21 Activity in perirhinal and entorhinal cortex predicts perceived visual similarities among category exemplars with highest precision Ferko, Kayla M Blumenthal, Anna Martin, Chris B Proklova, Daria Minos, Alexander N Saksida, Lisa M Bussey, Timothy J Khan, Ali R Köhler, Stefan eLife Neuroscience Vision neuroscience has made great strides in understanding the hierarchical organization of object representations along the ventral visual stream (VVS). How VVS representations capture fine-grained visual similarities between objects that observers subjectively perceive has received limited examination so far. In the current study, we addressed this question by focussing on perceived visual similarities among subordinate exemplars of real-world categories. We hypothesized that these perceived similarities are reflected with highest fidelity in neural activity patterns downstream from inferotemporal regions, namely in perirhinal (PrC) and anterolateral entorhinal cortex (alErC) in the medial temporal lobe. To address this issue with functional magnetic resonance imaging (fMRI), we administered a modified 1-back task that required discrimination between category exemplars as well as categorization. Further, we obtained observer-specific ratings of perceived visual similarities, which predicted behavioural discrimination performance during scanning. As anticipated, we found that activity patterns in PrC and alErC predicted the structure of perceived visual similarity relationships among category exemplars, including its observer-specific component, with higher precision than any other VVS region. Our findings provide new evidence that subjective aspects of object perception that rely on fine-grained visual differentiation are reflected with highest fidelity in the medial temporal lobe. eLife Sciences Publications, Ltd 2022-03-21 /pmc/articles/PMC9020819/ /pubmed/35311645 http://dx.doi.org/10.7554/eLife.66884 Text en © 2022, Ferko et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Ferko, Kayla M
Blumenthal, Anna
Martin, Chris B
Proklova, Daria
Minos, Alexander N
Saksida, Lisa M
Bussey, Timothy J
Khan, Ali R
Köhler, Stefan
Activity in perirhinal and entorhinal cortex predicts perceived visual similarities among category exemplars with highest precision
title Activity in perirhinal and entorhinal cortex predicts perceived visual similarities among category exemplars with highest precision
title_full Activity in perirhinal and entorhinal cortex predicts perceived visual similarities among category exemplars with highest precision
title_fullStr Activity in perirhinal and entorhinal cortex predicts perceived visual similarities among category exemplars with highest precision
title_full_unstemmed Activity in perirhinal and entorhinal cortex predicts perceived visual similarities among category exemplars with highest precision
title_short Activity in perirhinal and entorhinal cortex predicts perceived visual similarities among category exemplars with highest precision
title_sort activity in perirhinal and entorhinal cortex predicts perceived visual similarities among category exemplars with highest precision
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020819/
https://www.ncbi.nlm.nih.gov/pubmed/35311645
http://dx.doi.org/10.7554/eLife.66884
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