A dual-antigen self-amplifying RNA SARS-CoV-2 vaccine induces potent humoral and cellular immune responses and protects against SARS-CoV-2 variants through T cell-mediated immunity

Self-amplifying RNA vaccines may induce equivalent or more potent immune responses at lower doses compared to non-replicating mRNA vaccines via amplified antigen expression. In this paper, we demonstrate that 1 μg of an LNP-formulated dual-antigen self-amplifying RNA vaccine (ZIP1642), encoding both...

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Detalles Bibliográficos
Autores principales: McCafferty, Sean, Haque, A.K.M. Ashiqul, Vandierendonck, Aster, Weidensee, Brian, Plovyt, Magalie, Stuchlíková, Magdalena, François, Nathalie, Valembois, Sophie, Heyndrickx, Leo, Michiels, Johan, Ariën, Kevin K., Vandekerckhove, Linos, Abdelnabi, Rana, Foo, Caroline S., Neyts, Johan, Sahu, Itishri, Sanders, Niek N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020838/
https://www.ncbi.nlm.nih.gov/pubmed/35450821
http://dx.doi.org/10.1016/j.ymthe.2022.04.014

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