Potential Mechanisms of COVID-19-related Intracranial Hemorrhage Due to Temporary Depletion of Vitamin K-dependent Coagulation Factors: An Illustrative Case

Coronavirus disease 2019 (COVID-19)-related intracranial hemorrhage (ICH) is believed to be associated with at least one known risk factor for ICH, such as hypertension, hyperlipidemia, diabetes mellitus, severe pneumonia, or anticoagulation therapy. However, in this study, we report a case of ICH i...

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Autores principales: SHINODA, Narihide, TAMURA, Shogo, MORI, Masafumi, NAKAMURA, Mitsugu, KOROSUE, Kazuyoshi, KOSE, Shigeru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Neurosurgical Society 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020866/
https://www.ncbi.nlm.nih.gov/pubmed/35493535
http://dx.doi.org/10.2176/jns-nmc.2021-0295
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author SHINODA, Narihide
TAMURA, Shogo
MORI, Masafumi
NAKAMURA, Mitsugu
KOROSUE, Kazuyoshi
KOSE, Shigeru
author_facet SHINODA, Narihide
TAMURA, Shogo
MORI, Masafumi
NAKAMURA, Mitsugu
KOROSUE, Kazuyoshi
KOSE, Shigeru
author_sort SHINODA, Narihide
collection PubMed
description Coronavirus disease 2019 (COVID-19)-related intracranial hemorrhage (ICH) is believed to be associated with at least one known risk factor for ICH, such as hypertension, hyperlipidemia, diabetes mellitus, severe pneumonia, or anticoagulation therapy. However, in this study, we report a case of ICH in a 14-year-old boy with mild COVID-19 infection without pneumonia who had no such risk factors. The only abnormal laboratory finding was temporary depletion of vitamin K-dependent coagulation factors. This case indicates that COVID-19 infection may cause simultaneous asymptomatic intracranial microhemorrhages and temporary depletion of vitamin K-dependent coagulation factors. This temporary depletion might transform the intracranial microhemorrhages into symptomatic ICH.
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spelling pubmed-90208662022-04-28 Potential Mechanisms of COVID-19-related Intracranial Hemorrhage Due to Temporary Depletion of Vitamin K-dependent Coagulation Factors: An Illustrative Case SHINODA, Narihide TAMURA, Shogo MORI, Masafumi NAKAMURA, Mitsugu KOROSUE, Kazuyoshi KOSE, Shigeru NMC Case Rep J Case Report Coronavirus disease 2019 (COVID-19)-related intracranial hemorrhage (ICH) is believed to be associated with at least one known risk factor for ICH, such as hypertension, hyperlipidemia, diabetes mellitus, severe pneumonia, or anticoagulation therapy. However, in this study, we report a case of ICH in a 14-year-old boy with mild COVID-19 infection without pneumonia who had no such risk factors. The only abnormal laboratory finding was temporary depletion of vitamin K-dependent coagulation factors. This case indicates that COVID-19 infection may cause simultaneous asymptomatic intracranial microhemorrhages and temporary depletion of vitamin K-dependent coagulation factors. This temporary depletion might transform the intracranial microhemorrhages into symptomatic ICH. The Japan Neurosurgical Society 2022-04-01 /pmc/articles/PMC9020866/ /pubmed/35493535 http://dx.doi.org/10.2176/jns-nmc.2021-0295 Text en © 2022 The Japan Neurosurgical Society https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives International License.
spellingShingle Case Report
SHINODA, Narihide
TAMURA, Shogo
MORI, Masafumi
NAKAMURA, Mitsugu
KOROSUE, Kazuyoshi
KOSE, Shigeru
Potential Mechanisms of COVID-19-related Intracranial Hemorrhage Due to Temporary Depletion of Vitamin K-dependent Coagulation Factors: An Illustrative Case
title Potential Mechanisms of COVID-19-related Intracranial Hemorrhage Due to Temporary Depletion of Vitamin K-dependent Coagulation Factors: An Illustrative Case
title_full Potential Mechanisms of COVID-19-related Intracranial Hemorrhage Due to Temporary Depletion of Vitamin K-dependent Coagulation Factors: An Illustrative Case
title_fullStr Potential Mechanisms of COVID-19-related Intracranial Hemorrhage Due to Temporary Depletion of Vitamin K-dependent Coagulation Factors: An Illustrative Case
title_full_unstemmed Potential Mechanisms of COVID-19-related Intracranial Hemorrhage Due to Temporary Depletion of Vitamin K-dependent Coagulation Factors: An Illustrative Case
title_short Potential Mechanisms of COVID-19-related Intracranial Hemorrhage Due to Temporary Depletion of Vitamin K-dependent Coagulation Factors: An Illustrative Case
title_sort potential mechanisms of covid-19-related intracranial hemorrhage due to temporary depletion of vitamin k-dependent coagulation factors: an illustrative case
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020866/
https://www.ncbi.nlm.nih.gov/pubmed/35493535
http://dx.doi.org/10.2176/jns-nmc.2021-0295
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