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Lupeol Stearate Accelerates Healing and Prevents Recurrence of Gastric Ulcer in Rodents

OBJECTIVE: The focus of this study was to evaluate the gastric healing effect of lupeol stearate (LS) and its ability to minimize ulcer recurrence in rodents. METHODS: To evaluate the gastric healing properties of LS, rats were subjected to 80% acetic acid-induced ulcer model and treated with vehicl...

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Autores principales: Somensi, Lincon Bordignon, Costa, Philipe, Boeing, Thaise, Bolda Mariano, Luísa Nathália, de Gregório, Elizama, E Silva, Aline Teixeira Maciel, Longo, Bruna, Locatelli, Claudriana, de Souza, Priscila, Magalhães, Cássia Gonçalves, Pains Duarte, Lucienir, da Silva, Luisa Mota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020945/
https://www.ncbi.nlm.nih.gov/pubmed/35463093
http://dx.doi.org/10.1155/2022/6134128
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author Somensi, Lincon Bordignon
Costa, Philipe
Boeing, Thaise
Bolda Mariano, Luísa Nathália
de Gregório, Elizama
E Silva, Aline Teixeira Maciel
Longo, Bruna
Locatelli, Claudriana
de Souza, Priscila
Magalhães, Cássia Gonçalves
Pains Duarte, Lucienir
da Silva, Luisa Mota
author_facet Somensi, Lincon Bordignon
Costa, Philipe
Boeing, Thaise
Bolda Mariano, Luísa Nathália
de Gregório, Elizama
E Silva, Aline Teixeira Maciel
Longo, Bruna
Locatelli, Claudriana
de Souza, Priscila
Magalhães, Cássia Gonçalves
Pains Duarte, Lucienir
da Silva, Luisa Mota
author_sort Somensi, Lincon Bordignon
collection PubMed
description OBJECTIVE: The focus of this study was to evaluate the gastric healing effect of lupeol stearate (LS) and its ability to minimize ulcer recurrence in rodents. METHODS: To evaluate the gastric healing properties of LS, rats were subjected to 80% acetic acid-induced ulcer model and treated with vehicle, LS (1 mg/kg, p.o.), or omeprazole (20 mg/kg, p.o.), twice daily by seven days. The gastric ulcers were evaluated macroscopically, histologically, and biochemically. To evaluate the effects of LS in gastric ulcer recurrence, mice were ulcerated with 10% acetic acid and treated with vehicle, LS (1 mg/kg, p.o.), or ranitidine (100 mg/kg, p.o.), twice a day for ten days. Then, ulcer recurrence in these animals was induced by IL-1β at five days after the treatment period. RESULTS: The oral treatment with LS accelerated gastric healing by 63% in rats compared to the vehicle group, evidenced by histological improvement and increased gastric mucin levels. Moreover, the gastric healing effects of LS in rats were accompanied by an elevation in glutathione S-transferase activity and a reduction in myeloperoxidase activity. Furthermore, the LS treatment reduced the recurred lesions in mice. CONCLUSIONS: The oral treatment of LS accelerates gastric healing in rats by favoring mucus production and reducing neutrophil migration, and it also can reduce ulcer recurrence. These data highlighted this compound as promising for developing new pharmacological strategies for the management of gastric ulcer.
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spelling pubmed-90209452022-04-21 Lupeol Stearate Accelerates Healing and Prevents Recurrence of Gastric Ulcer in Rodents Somensi, Lincon Bordignon Costa, Philipe Boeing, Thaise Bolda Mariano, Luísa Nathália de Gregório, Elizama E Silva, Aline Teixeira Maciel Longo, Bruna Locatelli, Claudriana de Souza, Priscila Magalhães, Cássia Gonçalves Pains Duarte, Lucienir da Silva, Luisa Mota Evid Based Complement Alternat Med Research Article OBJECTIVE: The focus of this study was to evaluate the gastric healing effect of lupeol stearate (LS) and its ability to minimize ulcer recurrence in rodents. METHODS: To evaluate the gastric healing properties of LS, rats were subjected to 80% acetic acid-induced ulcer model and treated with vehicle, LS (1 mg/kg, p.o.), or omeprazole (20 mg/kg, p.o.), twice daily by seven days. The gastric ulcers were evaluated macroscopically, histologically, and biochemically. To evaluate the effects of LS in gastric ulcer recurrence, mice were ulcerated with 10% acetic acid and treated with vehicle, LS (1 mg/kg, p.o.), or ranitidine (100 mg/kg, p.o.), twice a day for ten days. Then, ulcer recurrence in these animals was induced by IL-1β at five days after the treatment period. RESULTS: The oral treatment with LS accelerated gastric healing by 63% in rats compared to the vehicle group, evidenced by histological improvement and increased gastric mucin levels. Moreover, the gastric healing effects of LS in rats were accompanied by an elevation in glutathione S-transferase activity and a reduction in myeloperoxidase activity. Furthermore, the LS treatment reduced the recurred lesions in mice. CONCLUSIONS: The oral treatment of LS accelerates gastric healing in rats by favoring mucus production and reducing neutrophil migration, and it also can reduce ulcer recurrence. These data highlighted this compound as promising for developing new pharmacological strategies for the management of gastric ulcer. Hindawi 2022-04-13 /pmc/articles/PMC9020945/ /pubmed/35463093 http://dx.doi.org/10.1155/2022/6134128 Text en Copyright © 2022 Lincon Bordignon Somensi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Somensi, Lincon Bordignon
Costa, Philipe
Boeing, Thaise
Bolda Mariano, Luísa Nathália
de Gregório, Elizama
E Silva, Aline Teixeira Maciel
Longo, Bruna
Locatelli, Claudriana
de Souza, Priscila
Magalhães, Cássia Gonçalves
Pains Duarte, Lucienir
da Silva, Luisa Mota
Lupeol Stearate Accelerates Healing and Prevents Recurrence of Gastric Ulcer in Rodents
title Lupeol Stearate Accelerates Healing and Prevents Recurrence of Gastric Ulcer in Rodents
title_full Lupeol Stearate Accelerates Healing and Prevents Recurrence of Gastric Ulcer in Rodents
title_fullStr Lupeol Stearate Accelerates Healing and Prevents Recurrence of Gastric Ulcer in Rodents
title_full_unstemmed Lupeol Stearate Accelerates Healing and Prevents Recurrence of Gastric Ulcer in Rodents
title_short Lupeol Stearate Accelerates Healing and Prevents Recurrence of Gastric Ulcer in Rodents
title_sort lupeol stearate accelerates healing and prevents recurrence of gastric ulcer in rodents
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9020945/
https://www.ncbi.nlm.nih.gov/pubmed/35463093
http://dx.doi.org/10.1155/2022/6134128
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