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Incidence and Distribution of New Renal Cell Carcinoma Cases: 27-Year Trends from a Statewide Cancer Registry
Nationwide databases have implicated an increased incidence of renal cell carcinoma (RCC). The Pennsylvania (PA) Cancer Registry was queried to better define incidence, geographic distribution, and statewide trends of new RCC cases over a 27-year period. JoinPoint Trend Analysis Software modeled ave...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Codon Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021010/ https://www.ncbi.nlm.nih.gov/pubmed/35528728 http://dx.doi.org/10.15586/jkcvhl.v9i2.219 |
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author | Alzubaidi, Ahmad N. Sekoulopoulos, Stephen Pham, Jonathan Walter, Vonn Fuletra, Jay G. Raman, Jay D. |
author_facet | Alzubaidi, Ahmad N. Sekoulopoulos, Stephen Pham, Jonathan Walter, Vonn Fuletra, Jay G. Raman, Jay D. |
author_sort | Alzubaidi, Ahmad N. |
collection | PubMed |
description | Nationwide databases have implicated an increased incidence of renal cell carcinoma (RCC). The Pennsylvania (PA) Cancer Registry was queried to better define incidence, geographic distribution, and statewide trends of new RCC cases over a 27-year period. JoinPoint Trend Analysis Software modeled average annual percent changes (APCs) in age-adjusted rates (AAR). Maps plotting county-level incidence rates and stage distribution of disease across the state in 5-year time intervals were created using R 4.0.2 software. Overall, 59,628 cases of RCC were recorded in PA from 1990 to 2017. Eighty six percent of patients were >50 years of age, 61% were males, and 89% were Caucasian. Stage distribution using the SEER staging system included 64% local, 17% regional, and 16% distant. Over the study interval, AAR of all RCC cases increased from 9.9 to 18.0 patients per 100,000 population with an APC of 2.3% (p < 0.01). AAR of local disease increased from 5.4 to 12.7 patients per 100,000 population with an APC of 3.2% (p < 0.01). AAR of regional disease also increased from 1.9 to 2.9 patients per 100,000 population with an APC of 1.0% (p = 0.01). Younger patients (<50 years) had a greater rate of increase than older counterparts (APC 3.8% vs. 2.0%, p < 0.05). Geospatial investigation of new RCC cases noted certain geographic concentrations of greater disease incidence. The incidence of RCC in PA has increased over the past 27 years in PA. One-third of the cases are regional or metastatic at presentation and rates of increase were most notable in younger patients. |
format | Online Article Text |
id | pubmed-9021010 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Codon Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-90210102022-05-06 Incidence and Distribution of New Renal Cell Carcinoma Cases: 27-Year Trends from a Statewide Cancer Registry Alzubaidi, Ahmad N. Sekoulopoulos, Stephen Pham, Jonathan Walter, Vonn Fuletra, Jay G. Raman, Jay D. J Kidney Cancer VHL Kidney Cancer: Original Article Nationwide databases have implicated an increased incidence of renal cell carcinoma (RCC). The Pennsylvania (PA) Cancer Registry was queried to better define incidence, geographic distribution, and statewide trends of new RCC cases over a 27-year period. JoinPoint Trend Analysis Software modeled average annual percent changes (APCs) in age-adjusted rates (AAR). Maps plotting county-level incidence rates and stage distribution of disease across the state in 5-year time intervals were created using R 4.0.2 software. Overall, 59,628 cases of RCC were recorded in PA from 1990 to 2017. Eighty six percent of patients were >50 years of age, 61% were males, and 89% were Caucasian. Stage distribution using the SEER staging system included 64% local, 17% regional, and 16% distant. Over the study interval, AAR of all RCC cases increased from 9.9 to 18.0 patients per 100,000 population with an APC of 2.3% (p < 0.01). AAR of local disease increased from 5.4 to 12.7 patients per 100,000 population with an APC of 3.2% (p < 0.01). AAR of regional disease also increased from 1.9 to 2.9 patients per 100,000 population with an APC of 1.0% (p = 0.01). Younger patients (<50 years) had a greater rate of increase than older counterparts (APC 3.8% vs. 2.0%, p < 0.05). Geospatial investigation of new RCC cases noted certain geographic concentrations of greater disease incidence. The incidence of RCC in PA has increased over the past 27 years in PA. One-third of the cases are regional or metastatic at presentation and rates of increase were most notable in younger patients. Codon Publications 2022-04-18 /pmc/articles/PMC9021010/ /pubmed/35528728 http://dx.doi.org/10.15586/jkcvhl.v9i2.219 Text en Copyright: Alzubaidi A.N, et al. https://creativecommons.org/licenses/by/4.0/License: This open access article is licensed under Creative Commons Attribution 4.0 International (CC BY 4.0). http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Kidney Cancer: Original Article Alzubaidi, Ahmad N. Sekoulopoulos, Stephen Pham, Jonathan Walter, Vonn Fuletra, Jay G. Raman, Jay D. Incidence and Distribution of New Renal Cell Carcinoma Cases: 27-Year Trends from a Statewide Cancer Registry |
title | Incidence and Distribution of New Renal Cell Carcinoma Cases: 27-Year Trends from a Statewide Cancer Registry |
title_full | Incidence and Distribution of New Renal Cell Carcinoma Cases: 27-Year Trends from a Statewide Cancer Registry |
title_fullStr | Incidence and Distribution of New Renal Cell Carcinoma Cases: 27-Year Trends from a Statewide Cancer Registry |
title_full_unstemmed | Incidence and Distribution of New Renal Cell Carcinoma Cases: 27-Year Trends from a Statewide Cancer Registry |
title_short | Incidence and Distribution of New Renal Cell Carcinoma Cases: 27-Year Trends from a Statewide Cancer Registry |
title_sort | incidence and distribution of new renal cell carcinoma cases: 27-year trends from a statewide cancer registry |
topic | Kidney Cancer: Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021010/ https://www.ncbi.nlm.nih.gov/pubmed/35528728 http://dx.doi.org/10.15586/jkcvhl.v9i2.219 |
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