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Incidence and Distribution of New Renal Cell Carcinoma Cases: 27-Year Trends from a Statewide Cancer Registry

Nationwide databases have implicated an increased incidence of renal cell carcinoma (RCC). The Pennsylvania (PA) Cancer Registry was queried to better define incidence, geographic distribution, and statewide trends of new RCC cases over a 27-year period. JoinPoint Trend Analysis Software modeled ave...

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Autores principales: Alzubaidi, Ahmad N., Sekoulopoulos, Stephen, Pham, Jonathan, Walter, Vonn, Fuletra, Jay G., Raman, Jay D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Codon Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021010/
https://www.ncbi.nlm.nih.gov/pubmed/35528728
http://dx.doi.org/10.15586/jkcvhl.v9i2.219
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author Alzubaidi, Ahmad N.
Sekoulopoulos, Stephen
Pham, Jonathan
Walter, Vonn
Fuletra, Jay G.
Raman, Jay D.
author_facet Alzubaidi, Ahmad N.
Sekoulopoulos, Stephen
Pham, Jonathan
Walter, Vonn
Fuletra, Jay G.
Raman, Jay D.
author_sort Alzubaidi, Ahmad N.
collection PubMed
description Nationwide databases have implicated an increased incidence of renal cell carcinoma (RCC). The Pennsylvania (PA) Cancer Registry was queried to better define incidence, geographic distribution, and statewide trends of new RCC cases over a 27-year period. JoinPoint Trend Analysis Software modeled average annual percent changes (APCs) in age-adjusted rates (AAR). Maps plotting county-level incidence rates and stage distribution of disease across the state in 5-year time intervals were created using R 4.0.2 software. Overall, 59,628 cases of RCC were recorded in PA from 1990 to 2017. Eighty six percent of patients were >50 years of age, 61% were males, and 89% were Caucasian. Stage distribution using the SEER staging system included 64% local, 17% regional, and 16% distant. Over the study interval, AAR of all RCC cases increased from 9.9 to 18.0 patients per 100,000 population with an APC of 2.3% (p < 0.01). AAR of local disease increased from 5.4 to 12.7 patients per 100,000 population with an APC of 3.2% (p < 0.01). AAR of regional disease also increased from 1.9 to 2.9 patients per 100,000 population with an APC of 1.0% (p = 0.01). Younger patients (<50 years) had a greater rate of increase than older counterparts (APC 3.8% vs. 2.0%, p < 0.05). Geospatial investigation of new RCC cases noted certain geographic concentrations of greater disease incidence. The incidence of RCC in PA has increased over the past 27 years in PA. One-third of the cases are regional or metastatic at presentation and rates of increase were most notable in younger patients.
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spelling pubmed-90210102022-05-06 Incidence and Distribution of New Renal Cell Carcinoma Cases: 27-Year Trends from a Statewide Cancer Registry Alzubaidi, Ahmad N. Sekoulopoulos, Stephen Pham, Jonathan Walter, Vonn Fuletra, Jay G. Raman, Jay D. J Kidney Cancer VHL Kidney Cancer: Original Article Nationwide databases have implicated an increased incidence of renal cell carcinoma (RCC). The Pennsylvania (PA) Cancer Registry was queried to better define incidence, geographic distribution, and statewide trends of new RCC cases over a 27-year period. JoinPoint Trend Analysis Software modeled average annual percent changes (APCs) in age-adjusted rates (AAR). Maps plotting county-level incidence rates and stage distribution of disease across the state in 5-year time intervals were created using R 4.0.2 software. Overall, 59,628 cases of RCC were recorded in PA from 1990 to 2017. Eighty six percent of patients were >50 years of age, 61% were males, and 89% were Caucasian. Stage distribution using the SEER staging system included 64% local, 17% regional, and 16% distant. Over the study interval, AAR of all RCC cases increased from 9.9 to 18.0 patients per 100,000 population with an APC of 2.3% (p < 0.01). AAR of local disease increased from 5.4 to 12.7 patients per 100,000 population with an APC of 3.2% (p < 0.01). AAR of regional disease also increased from 1.9 to 2.9 patients per 100,000 population with an APC of 1.0% (p = 0.01). Younger patients (<50 years) had a greater rate of increase than older counterparts (APC 3.8% vs. 2.0%, p < 0.05). Geospatial investigation of new RCC cases noted certain geographic concentrations of greater disease incidence. The incidence of RCC in PA has increased over the past 27 years in PA. One-third of the cases are regional or metastatic at presentation and rates of increase were most notable in younger patients. Codon Publications 2022-04-18 /pmc/articles/PMC9021010/ /pubmed/35528728 http://dx.doi.org/10.15586/jkcvhl.v9i2.219 Text en Copyright: Alzubaidi A.N, et al. https://creativecommons.org/licenses/by/4.0/License: This open access article is licensed under Creative Commons Attribution 4.0 International (CC BY 4.0). http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Kidney Cancer: Original Article
Alzubaidi, Ahmad N.
Sekoulopoulos, Stephen
Pham, Jonathan
Walter, Vonn
Fuletra, Jay G.
Raman, Jay D.
Incidence and Distribution of New Renal Cell Carcinoma Cases: 27-Year Trends from a Statewide Cancer Registry
title Incidence and Distribution of New Renal Cell Carcinoma Cases: 27-Year Trends from a Statewide Cancer Registry
title_full Incidence and Distribution of New Renal Cell Carcinoma Cases: 27-Year Trends from a Statewide Cancer Registry
title_fullStr Incidence and Distribution of New Renal Cell Carcinoma Cases: 27-Year Trends from a Statewide Cancer Registry
title_full_unstemmed Incidence and Distribution of New Renal Cell Carcinoma Cases: 27-Year Trends from a Statewide Cancer Registry
title_short Incidence and Distribution of New Renal Cell Carcinoma Cases: 27-Year Trends from a Statewide Cancer Registry
title_sort incidence and distribution of new renal cell carcinoma cases: 27-year trends from a statewide cancer registry
topic Kidney Cancer: Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021010/
https://www.ncbi.nlm.nih.gov/pubmed/35528728
http://dx.doi.org/10.15586/jkcvhl.v9i2.219
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