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Thymidine phosphorylase induction by ionizing radiation antagonizes 5-fluorouracil resistance in human ductal pancreatic adenocarcinoma

Chemoresistance in pancreatic ductal adenocarcinoma (PDAC) frequently contributes to failure of systemic therapy. While the radiosensitizing properties of 5-fluorouracil (FU) are well known, it is unknown whether ionizing radiation (IR) sensitizes towards FU cytotoxicity. Here, we hypothesize that u...

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Detalles Bibliográficos
Autores principales:	Lee, Lucas D., Pozios, Ioannis, Liu, Verena, Nachbichler, Silke B., Böhmer, Dirk, Kamphues, Carsten, Beyer, Katharina, Bruns, Christiane J., Kreis, Martin E., Seeliger, Hendrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021112/ https://www.ncbi.nlm.nih.gov/pubmed/35084511 http://dx.doi.org/10.1007/s00411-022-00962-w

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