The caspase-2 substrate p54nrb exhibits a multifaceted role in tumor cell death susceptibility via gene regulatory functions

Caspase-2 represents an evolutionary conserved caspase, which plays a role in genotoxic stress-induced apoptosis, ageing-related metabolic changes, and in deleting aneuploid cells in tumors. Genetic deletion of caspase-2 leads to increased tumor susceptibility in vivo. The exact downstream signaling...

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Detalles Bibliográficos
Autores principales: Eichler, Madeleine, Distler, Ute, Nasrullah, Usman, Krishnan, Aswini, Kaulich, Manuel, Husnjak, Koraljka, Eberhardt, Wolfgang, Rajalingam, Krishnaraj, Tenzer, Stefan, Pfeilschifter, Josef, Imre, Gergely
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021192/
https://www.ncbi.nlm.nih.gov/pubmed/35444189
http://dx.doi.org/10.1038/s41419-022-04829-2

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