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Cdk5 phosphorylation-induced SIRT2 nuclear translocation promotes the death of dopaminergic neurons in Parkinson’s disease

NAD-dependent protein deacetylase Sirtuin 2 (SIRT2), which regulates several cellular pathways by deacetylating multiple substrates, has been extensively studied in the context of Parkinson’s disease (PD). Although several studies based on the MPTP model of PD show that SIRT2 deletion can protect ag...

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Detalles Bibliográficos
Autores principales:	Yan, Jianguo, Zhang, Pei, Tan, Jie, Li, Mao, Xu, Xingfeng, Shao, Xiaoyun, Fang, Fang, Zou, Zhenyou, Zhou, Yali, Tian, Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021196/ https://www.ncbi.nlm.nih.gov/pubmed/35443760 http://dx.doi.org/10.1038/s41531-022-00311-0

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