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The BCL-2 inhibitor ABT-199/venetoclax synergizes with proteasome inhibition via transactivation of the MCL-1 antagonist NOXA

Enhanced expression of anti-apoptotic B-cell lymphoma 2 (BCL-2) protein is frequent in cancer. Targeting of BCL-2 with the specific inhibitor ABT-199 (Venetoclax) has significant clinical activity in malignant diseases such as chronic lymphocytic leukemia and multiple myeloma. The small molecule dru...

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Detalles Bibliográficos
Autores principales:	Weller, Sandra, Toennießen, Astrid, Schaefer, Benjamin, Beigl, Tobias, Muenchow, Alina, Böpple, Kathrin, Hofmann, Ute, Gillissen, Bernhard F., Aulitzky, Walter E., Kopp, Hans-Georg, Essmann, Frank
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021261/ https://www.ncbi.nlm.nih.gov/pubmed/35443750 http://dx.doi.org/10.1038/s41420-022-01009-1

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