RNA polymerase II pausing factor NELF in CD8(+) T cells promotes antitumor immunity

T cell factor 1 (TCF1) is required for memory and stem-like CD8(+) T cell functions. How TCF1 partners with other transcription factors to regulate transcription remains unclear. Here we show that negative elongation factor (NELF), an RNA polymerase II (Pol II) pausing factor, cooperates with TCF1 i...

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Detalles Bibliográficos
Autores principales: Wu, Bogang, Zhang, Xiaowen, Chiang, Huai-Chin, Pan, Haihui, Yuan, Bin, Mitra, Payal, Qi, Leilei, Simonyan, Hayk, Young, Colin N., Yvon, Eric, Hu, Yanfen, Zhang, Nu, Li, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021285/
https://www.ncbi.nlm.nih.gov/pubmed/35444206
http://dx.doi.org/10.1038/s41467-022-29869-2

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