Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer’s disease mouse model

The defining features of Alzheimer’s disease (AD) include alterations in protein aggregation, immunity, lipid metabolism, synapses, and learning and memory. Of these, lipid abnormalities are the least understood. Here, we investigate the role of Stearoyl-CoA desaturase (SCD), a crucial regulator of...

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Detalles Bibliográficos
Autores principales: Hamilton, Laura K., Moquin-Beaudry, Gaël, Mangahas, Chenicka L., Pratesi, Federico, Aubin, Myriam, Aumont, Anne, Joppé, Sandra E., Légiot, Alexandre, Vachon, Annick, Plourde, Mélanie, Mounier, Catherine, Tétreault, Martine, Fernandes, Karl J. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021296/
https://www.ncbi.nlm.nih.gov/pubmed/35443751
http://dx.doi.org/10.1038/s41467-022-29506-y

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