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Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer’s disease mouse model
The defining features of Alzheimer’s disease (AD) include alterations in protein aggregation, immunity, lipid metabolism, synapses, and learning and memory. Of these, lipid abnormalities are the least understood. Here, we investigate the role of Stearoyl-CoA desaturase (SCD), a crucial regulator of...
Autores principales: | Hamilton, Laura K., Moquin-Beaudry, Gaël, Mangahas, Chenicka L., Pratesi, Federico, Aubin, Myriam, Aumont, Anne, Joppé, Sandra E., Légiot, Alexandre, Vachon, Annick, Plourde, Mélanie, Mounier, Catherine, Tétreault, Martine, Fernandes, Karl J. L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021296/ https://www.ncbi.nlm.nih.gov/pubmed/35443751 http://dx.doi.org/10.1038/s41467-022-29506-y |
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