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COVID-19 Pandemic Impact on Liver Donation in the Largest Brazilian Transplantation Center

BACKGROUND: COVID-19 has spread worldwide and has become a public health emergency and a pandemic of international concern. The solid organ donation system was no different. This study aimed to investigate the effect of COVID-19 on the liver transplant (LT) system in Brazilian territory. METHODS: We...

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Autores principales: Fortunato, Allana C, Pinheiro, Rafael S, Fernandes, Michel Ribeiro, Nacif, Lucas Souto, Arantes, Rubens Macedo, Rocha-Santos, Vinicius, Waisberg, Daniel Reis, De Martino, Rodrigo Bronze, Ducatti, Liliana, Haddad, Luciana Bertocco, Song, Alice Tung, Abdala, Edson, Andraus, Wellington, Carneiro-D'Albuquerque, Luiz Augusto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021359/
https://www.ncbi.nlm.nih.gov/pubmed/35811150
http://dx.doi.org/10.1016/j.transproceed.2022.03.045
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author Fortunato, Allana C
Pinheiro, Rafael S
Fernandes, Michel Ribeiro
Nacif, Lucas Souto
Arantes, Rubens Macedo
Rocha-Santos, Vinicius
Waisberg, Daniel Reis
De Martino, Rodrigo Bronze
Ducatti, Liliana
Haddad, Luciana Bertocco
Song, Alice Tung
Abdala, Edson
Andraus, Wellington
Carneiro-D'Albuquerque, Luiz Augusto
author_facet Fortunato, Allana C
Pinheiro, Rafael S
Fernandes, Michel Ribeiro
Nacif, Lucas Souto
Arantes, Rubens Macedo
Rocha-Santos, Vinicius
Waisberg, Daniel Reis
De Martino, Rodrigo Bronze
Ducatti, Liliana
Haddad, Luciana Bertocco
Song, Alice Tung
Abdala, Edson
Andraus, Wellington
Carneiro-D'Albuquerque, Luiz Augusto
author_sort Fortunato, Allana C
collection PubMed
description BACKGROUND: COVID-19 has spread worldwide and has become a public health emergency and a pandemic of international concern. The solid organ donation system was no different. This study aimed to investigate the effect of COVID-19 on the liver transplant (LT) system in Brazilian territory. METHODS: We retrospectively reviewed all liver donor records allocated in São Paulo State, Brazil, 1 year before and 1 year during the COVID-19 pandemic. We defined the pre–COVID-19 (PRE) period as between April 2019 and April 2020 and the post–COVID-19 (POST) period as between April 2020 and April 2021. Moreover, we compared LT performed in our institution during these periods. To evaluate outcomes, we compared 30-day survival after LT. RESULTS: In the PRE period, 1452 livers were offered for donation in São Paulo State and other Brazilian territories. Of these, 592 were used in LT. In the POST period, 1314 livers were offered for donation, but only 477 were used in LT. Organ refusal was higher in the POST period (P < .05). Our center performed 127 and 156 LTs in these periods, respectively, and an increase above 20% was significant (P = .039). There was no difference in 30-day survival between the periods (87.2% vs 87.9%, P > .5, respectively). CONCLUSIONS: The COVID-19 pandemic harmed potential and allocated donors and LTs performed. However, it is possible to maintain the LT volume of a transplant center without compromising survival outcomes through preventive strategies against COVID-19 propagation.
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spelling pubmed-90213592022-04-21 COVID-19 Pandemic Impact on Liver Donation in the Largest Brazilian Transplantation Center Fortunato, Allana C Pinheiro, Rafael S Fernandes, Michel Ribeiro Nacif, Lucas Souto Arantes, Rubens Macedo Rocha-Santos, Vinicius Waisberg, Daniel Reis De Martino, Rodrigo Bronze Ducatti, Liliana Haddad, Luciana Bertocco Song, Alice Tung Abdala, Edson Andraus, Wellington Carneiro-D'Albuquerque, Luiz Augusto Transplant Proc Article BACKGROUND: COVID-19 has spread worldwide and has become a public health emergency and a pandemic of international concern. The solid organ donation system was no different. This study aimed to investigate the effect of COVID-19 on the liver transplant (LT) system in Brazilian territory. METHODS: We retrospectively reviewed all liver donor records allocated in São Paulo State, Brazil, 1 year before and 1 year during the COVID-19 pandemic. We defined the pre–COVID-19 (PRE) period as between April 2019 and April 2020 and the post–COVID-19 (POST) period as between April 2020 and April 2021. Moreover, we compared LT performed in our institution during these periods. To evaluate outcomes, we compared 30-day survival after LT. RESULTS: In the PRE period, 1452 livers were offered for donation in São Paulo State and other Brazilian territories. Of these, 592 were used in LT. In the POST period, 1314 livers were offered for donation, but only 477 were used in LT. Organ refusal was higher in the POST period (P < .05). Our center performed 127 and 156 LTs in these periods, respectively, and an increase above 20% was significant (P = .039). There was no difference in 30-day survival between the periods (87.2% vs 87.9%, P > .5, respectively). CONCLUSIONS: The COVID-19 pandemic harmed potential and allocated donors and LTs performed. However, it is possible to maintain the LT volume of a transplant center without compromising survival outcomes through preventive strategies against COVID-19 propagation. Elsevier Inc. 2022-06 2022-04-21 /pmc/articles/PMC9021359/ /pubmed/35811150 http://dx.doi.org/10.1016/j.transproceed.2022.03.045 Text en © 2022 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Fortunato, Allana C
Pinheiro, Rafael S
Fernandes, Michel Ribeiro
Nacif, Lucas Souto
Arantes, Rubens Macedo
Rocha-Santos, Vinicius
Waisberg, Daniel Reis
De Martino, Rodrigo Bronze
Ducatti, Liliana
Haddad, Luciana Bertocco
Song, Alice Tung
Abdala, Edson
Andraus, Wellington
Carneiro-D'Albuquerque, Luiz Augusto
COVID-19 Pandemic Impact on Liver Donation in the Largest Brazilian Transplantation Center
title COVID-19 Pandemic Impact on Liver Donation in the Largest Brazilian Transplantation Center
title_full COVID-19 Pandemic Impact on Liver Donation in the Largest Brazilian Transplantation Center
title_fullStr COVID-19 Pandemic Impact on Liver Donation in the Largest Brazilian Transplantation Center
title_full_unstemmed COVID-19 Pandemic Impact on Liver Donation in the Largest Brazilian Transplantation Center
title_short COVID-19 Pandemic Impact on Liver Donation in the Largest Brazilian Transplantation Center
title_sort covid-19 pandemic impact on liver donation in the largest brazilian transplantation center
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021359/
https://www.ncbi.nlm.nih.gov/pubmed/35811150
http://dx.doi.org/10.1016/j.transproceed.2022.03.045
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