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Rational Design of a Gd(III)–Cu(II) Nanobooster for Chemodynamic Therapy Against Cancer Cells
Copper (II) containing coordination complexes have attracted much attention for chemodynamic therapy (CDT) against cancer cells. In this study, the bimetallic nanobooster [Gd(2)Cu(L)(2)(H(2)O)(10)]·6H(2)O was prepared by a solvothermal method based on tetrazole carboxylic acid ligand H(4)L [H(4)L =...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021535/ https://www.ncbi.nlm.nih.gov/pubmed/35464207 http://dx.doi.org/10.3389/fchem.2022.856495 |
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author | Shi, Xin-Ya Shen, Ting-Xiao Zhang, Ao-Lin Tan, Li-Tao Shen, Wen-Chang Zhong, Hai-Jiang Zhang, Shun-Lin Gu, Yu-Lan Shen, Lei |
author_facet | Shi, Xin-Ya Shen, Ting-Xiao Zhang, Ao-Lin Tan, Li-Tao Shen, Wen-Chang Zhong, Hai-Jiang Zhang, Shun-Lin Gu, Yu-Lan Shen, Lei |
author_sort | Shi, Xin-Ya |
collection | PubMed |
description | Copper (II) containing coordination complexes have attracted much attention for chemodynamic therapy (CDT) against cancer cells. In this study, the bimetallic nanobooster [Gd(2)Cu(L)(2)(H(2)O)(10)]·6H(2)O was prepared by a solvothermal method based on tetrazole carboxylic acid ligand H(4)L [H(4)L = 3,3-di (1H-tetrazol-5-yl) pentanedioic acid]. It showed considerable cytotoxicity toward three kinds of human cancer cells (HeLa, HepG2, and HT29). The MTT assay showed that the IC(50) (half-maximal inhibitory concentration) of the complex NPs on HeLa cells (4.9 μg/ml) is superior to that of HepG2 (11.1 μg/ml) and HT29 (5.5 μg/ml). This result showed that [Gd(2)Cu(L)(2)(H(2)O)(10)]·6H(2)O NPs can inhibit cell proliferation in vitro and may be potential candidates for chemodynamic therapy. In addition, the cytotoxicity was also confirmed by the trypan blue staining experiment. The results promise the great potential of Gd(III)–Cu(II) for CDT against cancer cells. |
format | Online Article Text |
id | pubmed-9021535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90215352022-04-22 Rational Design of a Gd(III)–Cu(II) Nanobooster for Chemodynamic Therapy Against Cancer Cells Shi, Xin-Ya Shen, Ting-Xiao Zhang, Ao-Lin Tan, Li-Tao Shen, Wen-Chang Zhong, Hai-Jiang Zhang, Shun-Lin Gu, Yu-Lan Shen, Lei Front Chem Chemistry Copper (II) containing coordination complexes have attracted much attention for chemodynamic therapy (CDT) against cancer cells. In this study, the bimetallic nanobooster [Gd(2)Cu(L)(2)(H(2)O)(10)]·6H(2)O was prepared by a solvothermal method based on tetrazole carboxylic acid ligand H(4)L [H(4)L = 3,3-di (1H-tetrazol-5-yl) pentanedioic acid]. It showed considerable cytotoxicity toward three kinds of human cancer cells (HeLa, HepG2, and HT29). The MTT assay showed that the IC(50) (half-maximal inhibitory concentration) of the complex NPs on HeLa cells (4.9 μg/ml) is superior to that of HepG2 (11.1 μg/ml) and HT29 (5.5 μg/ml). This result showed that [Gd(2)Cu(L)(2)(H(2)O)(10)]·6H(2)O NPs can inhibit cell proliferation in vitro and may be potential candidates for chemodynamic therapy. In addition, the cytotoxicity was also confirmed by the trypan blue staining experiment. The results promise the great potential of Gd(III)–Cu(II) for CDT against cancer cells. Frontiers Media S.A. 2022-04-07 /pmc/articles/PMC9021535/ /pubmed/35464207 http://dx.doi.org/10.3389/fchem.2022.856495 Text en Copyright © 2022 Shi, Shen, Zhang, Tan, Shen, Zhong, Zhang, Gu and Shen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Chemistry Shi, Xin-Ya Shen, Ting-Xiao Zhang, Ao-Lin Tan, Li-Tao Shen, Wen-Chang Zhong, Hai-Jiang Zhang, Shun-Lin Gu, Yu-Lan Shen, Lei Rational Design of a Gd(III)–Cu(II) Nanobooster for Chemodynamic Therapy Against Cancer Cells |
title | Rational Design of a Gd(III)–Cu(II) Nanobooster for Chemodynamic Therapy Against Cancer Cells |
title_full | Rational Design of a Gd(III)–Cu(II) Nanobooster for Chemodynamic Therapy Against Cancer Cells |
title_fullStr | Rational Design of a Gd(III)–Cu(II) Nanobooster for Chemodynamic Therapy Against Cancer Cells |
title_full_unstemmed | Rational Design of a Gd(III)–Cu(II) Nanobooster for Chemodynamic Therapy Against Cancer Cells |
title_short | Rational Design of a Gd(III)–Cu(II) Nanobooster for Chemodynamic Therapy Against Cancer Cells |
title_sort | rational design of a gd(iii)–cu(ii) nanobooster for chemodynamic therapy against cancer cells |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021535/ https://www.ncbi.nlm.nih.gov/pubmed/35464207 http://dx.doi.org/10.3389/fchem.2022.856495 |
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