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Macular Changes Observed on Optical Coherence Tomography Angiography in Patients Infected With Human Immunodeficiency Virus Without Infectious Retinopathy

PURPOSE: As the human immunodeficiency virus (HIV) pandemic is far from over, whether there are subclinical macular changes in HIV-positive patients is something that should not be overlooked. We aimed to apply optical coherence tomography angiography (OCTA) to assess the macular structure and micro...

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Autores principales: Du, Kui-Fang, Huang, Xiao-Jie, Chen, Chao, Kong, Wen-Jun, Xie, Lian-Yong, Dong, Hong-Wei, Wei, Wen-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021568/
https://www.ncbi.nlm.nih.gov/pubmed/35462995
http://dx.doi.org/10.3389/fmed.2022.820370
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author Du, Kui-Fang
Huang, Xiao-Jie
Chen, Chao
Kong, Wen-Jun
Xie, Lian-Yong
Dong, Hong-Wei
Wei, Wen-Bin
author_facet Du, Kui-Fang
Huang, Xiao-Jie
Chen, Chao
Kong, Wen-Jun
Xie, Lian-Yong
Dong, Hong-Wei
Wei, Wen-Bin
author_sort Du, Kui-Fang
collection PubMed
description PURPOSE: As the human immunodeficiency virus (HIV) pandemic is far from over, whether there are subclinical macular changes in HIV-positive patients is something that should not be overlooked. We aimed to apply optical coherence tomography angiography (OCTA) to assess the macular structure and microvasculature changes in patients with HIV without infectious retinopathy. METHODS: HIV-positive and -negative participants were included and classified into three groups: HIV-negative, HIV-positive, and HIV-positive with microvasculopathy. OCTA parameters regarding macular structure and microvasculature were analyzed. RESULTS: Compared with the HIV-negative group, the superficial retinal vessel density (VD) in the parafovea sectors and the whole Early Treatment of Diabetic Retinopathy Study (ETDRS) grid and the choroidal vascularity index (CVI) in the whole ETDRS grid were significantly decreased in the HIV-positive and HIV-positive with microvasculopathy groups (p < 0.05). No differences were found in OCTA parameters between the HIV-positive and HIV-positive with microvasculopathy groups. Retinal, retinal nerve fiber layer-ganglion cell layer-inner plexiform layer (RNFL-GCL-IPL), RNFL, GCL-IPL, and INL thickness showed a negative association with the duration of HIV diagnosis or antiretroviral therapy (ART) (all p < 0.05). All OCTA microvasculature parameters showed no association with HIV-related clinical variables (all p > 0.05). CONCLUSIONS: Subclinical macular changes existed in HIV-infected patients without clinical infectious retinopathy. Substructures from inner retinal layers might be associated with HIV infection or ART duration.
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spelling pubmed-90215682022-04-22 Macular Changes Observed on Optical Coherence Tomography Angiography in Patients Infected With Human Immunodeficiency Virus Without Infectious Retinopathy Du, Kui-Fang Huang, Xiao-Jie Chen, Chao Kong, Wen-Jun Xie, Lian-Yong Dong, Hong-Wei Wei, Wen-Bin Front Med (Lausanne) Medicine PURPOSE: As the human immunodeficiency virus (HIV) pandemic is far from over, whether there are subclinical macular changes in HIV-positive patients is something that should not be overlooked. We aimed to apply optical coherence tomography angiography (OCTA) to assess the macular structure and microvasculature changes in patients with HIV without infectious retinopathy. METHODS: HIV-positive and -negative participants were included and classified into three groups: HIV-negative, HIV-positive, and HIV-positive with microvasculopathy. OCTA parameters regarding macular structure and microvasculature were analyzed. RESULTS: Compared with the HIV-negative group, the superficial retinal vessel density (VD) in the parafovea sectors and the whole Early Treatment of Diabetic Retinopathy Study (ETDRS) grid and the choroidal vascularity index (CVI) in the whole ETDRS grid were significantly decreased in the HIV-positive and HIV-positive with microvasculopathy groups (p < 0.05). No differences were found in OCTA parameters between the HIV-positive and HIV-positive with microvasculopathy groups. Retinal, retinal nerve fiber layer-ganglion cell layer-inner plexiform layer (RNFL-GCL-IPL), RNFL, GCL-IPL, and INL thickness showed a negative association with the duration of HIV diagnosis or antiretroviral therapy (ART) (all p < 0.05). All OCTA microvasculature parameters showed no association with HIV-related clinical variables (all p > 0.05). CONCLUSIONS: Subclinical macular changes existed in HIV-infected patients without clinical infectious retinopathy. Substructures from inner retinal layers might be associated with HIV infection or ART duration. Frontiers Media S.A. 2022-04-07 /pmc/articles/PMC9021568/ /pubmed/35462995 http://dx.doi.org/10.3389/fmed.2022.820370 Text en Copyright © 2022 Du, Huang, Chen, Kong, Xie, Dong and Wei. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Du, Kui-Fang
Huang, Xiao-Jie
Chen, Chao
Kong, Wen-Jun
Xie, Lian-Yong
Dong, Hong-Wei
Wei, Wen-Bin
Macular Changes Observed on Optical Coherence Tomography Angiography in Patients Infected With Human Immunodeficiency Virus Without Infectious Retinopathy
title Macular Changes Observed on Optical Coherence Tomography Angiography in Patients Infected With Human Immunodeficiency Virus Without Infectious Retinopathy
title_full Macular Changes Observed on Optical Coherence Tomography Angiography in Patients Infected With Human Immunodeficiency Virus Without Infectious Retinopathy
title_fullStr Macular Changes Observed on Optical Coherence Tomography Angiography in Patients Infected With Human Immunodeficiency Virus Without Infectious Retinopathy
title_full_unstemmed Macular Changes Observed on Optical Coherence Tomography Angiography in Patients Infected With Human Immunodeficiency Virus Without Infectious Retinopathy
title_short Macular Changes Observed on Optical Coherence Tomography Angiography in Patients Infected With Human Immunodeficiency Virus Without Infectious Retinopathy
title_sort macular changes observed on optical coherence tomography angiography in patients infected with human immunodeficiency virus without infectious retinopathy
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021568/
https://www.ncbi.nlm.nih.gov/pubmed/35462995
http://dx.doi.org/10.3389/fmed.2022.820370
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