Case Report: Therapeutic and immunomodulatory effects of plasmapheresis in long-haul COVID

Many patients with COVID-19 experience a range of debilitating symptoms months after being infected, a syndrome termed long-haul COVID. A 68-year-old male presented with lung opacity, fatigue, physical and cognitive weaknesses, loss of smell and lymphocytopenia. After rounds of therapeutic plasma ex...

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Autores principales: Kiprov, Dobri D., Herskowitz, Ahvie, Kim, Daehwan, Lieb, Michael, Liu, Chao, Watanabe, Etsuko, Hoffman, Jan C., Rohe, Regina, Conboy, Michael J., Conboy, Irina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021669/
https://www.ncbi.nlm.nih.gov/pubmed/35464182
http://dx.doi.org/10.12688/f1000research.74534.2
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author Kiprov, Dobri D.
Herskowitz, Ahvie
Kim, Daehwan
Lieb, Michael
Liu, Chao
Watanabe, Etsuko
Hoffman, Jan C.
Rohe, Regina
Conboy, Michael J.
Conboy, Irina M.
author_facet Kiprov, Dobri D.
Herskowitz, Ahvie
Kim, Daehwan
Lieb, Michael
Liu, Chao
Watanabe, Etsuko
Hoffman, Jan C.
Rohe, Regina
Conboy, Michael J.
Conboy, Irina M.
author_sort Kiprov, Dobri D.
collection PubMed
description Many patients with COVID-19 experience a range of debilitating symptoms months after being infected, a syndrome termed long-haul COVID. A 68-year-old male presented with lung opacity, fatigue, physical and cognitive weaknesses, loss of smell and lymphocytopenia. After rounds of therapeutic plasma exchange (TPE), the patient returned to normal activities and work. Mechanistically in the patient’s peripheral blood mononuclear cells (PBMCs), markers of inflammatory macrophages diminished and markers of lymphocytes, including natural killer (NK) cells and cytotoxic CD8 T-cells, increased. Circulating inflammatory proteins diminished, while positive regulators of tissue repair increased. This case study suggests that TPE has the capacity to treat long-haul COVID.
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spelling pubmed-90216692022-04-21 Case Report: Therapeutic and immunomodulatory effects of plasmapheresis in long-haul COVID Kiprov, Dobri D. Herskowitz, Ahvie Kim, Daehwan Lieb, Michael Liu, Chao Watanabe, Etsuko Hoffman, Jan C. Rohe, Regina Conboy, Michael J. Conboy, Irina M. F1000Res Case Report Many patients with COVID-19 experience a range of debilitating symptoms months after being infected, a syndrome termed long-haul COVID. A 68-year-old male presented with lung opacity, fatigue, physical and cognitive weaknesses, loss of smell and lymphocytopenia. After rounds of therapeutic plasma exchange (TPE), the patient returned to normal activities and work. Mechanistically in the patient’s peripheral blood mononuclear cells (PBMCs), markers of inflammatory macrophages diminished and markers of lymphocytes, including natural killer (NK) cells and cytotoxic CD8 T-cells, increased. Circulating inflammatory proteins diminished, while positive regulators of tissue repair increased. This case study suggests that TPE has the capacity to treat long-haul COVID. F1000 Research Limited 2022-04-06 /pmc/articles/PMC9021669/ /pubmed/35464182 http://dx.doi.org/10.12688/f1000research.74534.2 Text en Copyright: © 2022 Kiprov DD et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kiprov, Dobri D.
Herskowitz, Ahvie
Kim, Daehwan
Lieb, Michael
Liu, Chao
Watanabe, Etsuko
Hoffman, Jan C.
Rohe, Regina
Conboy, Michael J.
Conboy, Irina M.
Case Report: Therapeutic and immunomodulatory effects of plasmapheresis in long-haul COVID
title Case Report: Therapeutic and immunomodulatory effects of plasmapheresis in long-haul COVID
title_full Case Report: Therapeutic and immunomodulatory effects of plasmapheresis in long-haul COVID
title_fullStr Case Report: Therapeutic and immunomodulatory effects of plasmapheresis in long-haul COVID
title_full_unstemmed Case Report: Therapeutic and immunomodulatory effects of plasmapheresis in long-haul COVID
title_short Case Report: Therapeutic and immunomodulatory effects of plasmapheresis in long-haul COVID
title_sort case report: therapeutic and immunomodulatory effects of plasmapheresis in long-haul covid
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021669/
https://www.ncbi.nlm.nih.gov/pubmed/35464182
http://dx.doi.org/10.12688/f1000research.74534.2
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