Can First-Dose Therapeutic Drug Monitoring Predict the Steady State Area Under the Blood Concentration-Time Curve of Busulfan in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation?

Busulfan has high intra-individual variability and possible time-dependent changes in clearance, which complicates therapeutic drug monitoring (TDM), as first dose sampling may not predict the steady state concentrations. In this study, we aimed to use Bayesian pharmacokinetic parameters estimated f...

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Detalles Bibliográficos
Autores principales: Alsultan, Abdullah, Albassam, Ahmed A., Alturki, Abdullah, Alsultan, Abdulrahman, Essa, Mohammed, Almuzzaini, Bader, Alfadhel, Salman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021690/
https://www.ncbi.nlm.nih.gov/pubmed/35463912
http://dx.doi.org/10.3389/fped.2022.834773

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