Effects of SGLT2 inhibitor on tumor‐releasing chemokines/cytokines in Hep3B and Huh7 cells

(a) Summary for SGLT2i‐induced alterations in 48 chemokines/cytokines in Hep3B and Huh7 cells. (b) SGLT2i‐induced changes in the medium CXCL1 level (each n = 4). (c) SGLT2i‐induced changes in the medium CXCL8 level (each n = 4). (d) SGLT2i‐induced changes in the medium CXCL10 level (each n = 4), (e)...

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Detalles Bibliográficos
Autores principales: Nakano, Dan, Kawaguchi, Takumi, Tsutsumi, Tsubasa, Hayakawa, Masako, Yoshio, Sachiyo, Koga, Hironori, Torimura, Takuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Publishing Asia Pty Ltd 2022
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021706/
https://www.ncbi.nlm.nih.gov/pubmed/35475201
http://dx.doi.org/10.1002/jgh3.12730
Descripción
Sumario:(a) Summary for SGLT2i‐induced alterations in 48 chemokines/cytokines in Hep3B and Huh7 cells. (b) SGLT2i‐induced changes in the medium CXCL1 level (each n = 4). (c) SGLT2i‐induced changes in the medium CXCL8 level (each n = 4). (d) SGLT2i‐induced changes in the medium CXCL10 level (each n = 4), (e) SGLT2i‐induced changes in the medium M‐CSF level (each n = 4). The SGLT2i‐induced significant changes in chemokines/cytokines are expressed as the percentage of control (the mean value of the control was set as 100%). CXCL, C‐X‐C motif chemokine ligand; G‐CSF, granulocyte colony‐stimulating factor; IL, interleukin; LIF, leukemia inhibitory factor; M‐CSF, macrophage colony‐stimulating factor; MIP‐1α, macrophage inflammatory protein‐1α; SDF‐1α, stromal‐cell‐derived factor‐1α; TNFα, tumor necrosis factor‐α; VEGF, vascular endothelial growth factor.[Image: see text]

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