Circular RNA and Its Roles in the Occurrence, Development, Diagnosis of Cancer

Circular RNAs (circRNAs) are non-coding single-stranded covalently closed circular RNA, mainly produced by reverse splicing of exons of precursor mRNAs (pre-mRNAs). The characteristics of high abundance, strong specificity, and good stability of circRNAs have been discovered. A large number of studi...

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Detalles Bibliográficos
Autores principales: Zhang, Yue, Zhang, Xinyi, Xu, Yumeng, Fang, Shikun, Ji, Ying, Lu, Ling, Xu, Wenrong, Qian, Hui, Liang, Zhao Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021756/
https://www.ncbi.nlm.nih.gov/pubmed/35463362
http://dx.doi.org/10.3389/fonc.2022.845703
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author Zhang, Yue
Zhang, Xinyi
Xu, Yumeng
Fang, Shikun
Ji, Ying
Lu, Ling
Xu, Wenrong
Qian, Hui
Liang, Zhao Feng
author_facet Zhang, Yue
Zhang, Xinyi
Xu, Yumeng
Fang, Shikun
Ji, Ying
Lu, Ling
Xu, Wenrong
Qian, Hui
Liang, Zhao Feng
author_sort Zhang, Yue
collection PubMed
description Circular RNAs (circRNAs) are non-coding single-stranded covalently closed circular RNA, mainly produced by reverse splicing of exons of precursor mRNAs (pre-mRNAs). The characteristics of high abundance, strong specificity, and good stability of circRNAs have been discovered. A large number of studies have reported its various functions and mechanisms in biological events, such as the occurrence and development of cancer. In this review, we focus on the classification, characterization, biogenesis, functions of circRNAs, and the latest advances in cancer research. The development of circRNAs as biomarkers in cancer diagnosis and treatment also provides new ideas for studying circRNAs research.
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spelling pubmed-90217562022-04-22 Circular RNA and Its Roles in the Occurrence, Development, Diagnosis of Cancer Zhang, Yue Zhang, Xinyi Xu, Yumeng Fang, Shikun Ji, Ying Lu, Ling Xu, Wenrong Qian, Hui Liang, Zhao Feng Front Oncol Oncology Circular RNAs (circRNAs) are non-coding single-stranded covalently closed circular RNA, mainly produced by reverse splicing of exons of precursor mRNAs (pre-mRNAs). The characteristics of high abundance, strong specificity, and good stability of circRNAs have been discovered. A large number of studies have reported its various functions and mechanisms in biological events, such as the occurrence and development of cancer. In this review, we focus on the classification, characterization, biogenesis, functions of circRNAs, and the latest advances in cancer research. The development of circRNAs as biomarkers in cancer diagnosis and treatment also provides new ideas for studying circRNAs research. Frontiers Media S.A. 2022-04-07 /pmc/articles/PMC9021756/ /pubmed/35463362 http://dx.doi.org/10.3389/fonc.2022.845703 Text en Copyright © 2022 Zhang, Zhang, Xu, Fang, Ji, Lu, Xu, Qian and Liang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhang, Yue
Zhang, Xinyi
Xu, Yumeng
Fang, Shikun
Ji, Ying
Lu, Ling
Xu, Wenrong
Qian, Hui
Liang, Zhao Feng
Circular RNA and Its Roles in the Occurrence, Development, Diagnosis of Cancer
title Circular RNA and Its Roles in the Occurrence, Development, Diagnosis of Cancer
title_full Circular RNA and Its Roles in the Occurrence, Development, Diagnosis of Cancer
title_fullStr Circular RNA and Its Roles in the Occurrence, Development, Diagnosis of Cancer
title_full_unstemmed Circular RNA and Its Roles in the Occurrence, Development, Diagnosis of Cancer
title_short Circular RNA and Its Roles in the Occurrence, Development, Diagnosis of Cancer
title_sort circular rna and its roles in the occurrence, development, diagnosis of cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021756/
https://www.ncbi.nlm.nih.gov/pubmed/35463362
http://dx.doi.org/10.3389/fonc.2022.845703
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