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Association Between Platelet Levels and 28-Day Mortality in Patients With Sepsis: A Retrospective Analysis of a Large Clinical Database MIMIC-IV

BACKGROUND: This research focused on evaluating the correlation between platelet count and sepsis prognosis, and even the dose-response relationship, in a cohort of American adults. METHOD: Platelet counts were recorded retrospectively after hospitalization for patients admitted to Beth Israel Deaco...

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Autores principales: Wang, Danni, Wang, Suning, Wu, Hao, Gao, Jiansheng, Huang, Kairong, Xu, Danhong, Ru, Huangyao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021789/
https://www.ncbi.nlm.nih.gov/pubmed/35463034
http://dx.doi.org/10.3389/fmed.2022.833996
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author Wang, Danni
Wang, Suning
Wu, Hao
Gao, Jiansheng
Huang, Kairong
Xu, Danhong
Ru, Huangyao
author_facet Wang, Danni
Wang, Suning
Wu, Hao
Gao, Jiansheng
Huang, Kairong
Xu, Danhong
Ru, Huangyao
author_sort Wang, Danni
collection PubMed
description BACKGROUND: This research focused on evaluating the correlation between platelet count and sepsis prognosis, and even the dose-response relationship, in a cohort of American adults. METHOD: Platelet counts were recorded retrospectively after hospitalization for patients admitted to Beth Israel Deaconess Medical Center’s intensive care unit between 2008 and 2019. On admission to the intensive care unit, sepsis patients were divided into four categories based on platelet counts (very low < 50 × 10(9)/L, intermediate-low 50 × 10(9)–100 × 10(9)/L, low 100 × 10(9)–150 × 10(9)/L, and normal ≥ 150 × 10(9)/L). A multivariate Cox proportional risk model was used to calculate the 28-day risk of mortality in sepsis based on baseline platelet counts, and a two-piece linear regression model was used to calculate the threshold effect. RESULTS: The risk of 28-day septic mortality was nearly 2-fold higher in the platelet very low group when compared to the low group (hazard ratios [HRs], 2.24; 95% confidence interval [CI], 1.92–2.6). Further analysis revealed a curvilinear association between platelets and the sepsis risk of death, with a saturation effect predicted at 100 × 10(9)/L. When platelet counts were below 100 × 10(9)/L, the risk of sepsis 28-day death decreased significantly with increasing platelet count levels (HR, 0.875; 95% CI, 0.84–0.90). CONCLUSION: When platelet count was less than 100 × 10(9)/L, it was a strong predictor of the potential risk of sepsis death, which is declined by 13% for every 10 × 10(9)/L growth in platelets. When platelet counts reach up to 100 × 10(9)/L, the probability of dying to sepsis within 28 days climbs by 1% for every 10 × 10(9)/L increase in platelet count.
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spelling pubmed-90217892022-04-22 Association Between Platelet Levels and 28-Day Mortality in Patients With Sepsis: A Retrospective Analysis of a Large Clinical Database MIMIC-IV Wang, Danni Wang, Suning Wu, Hao Gao, Jiansheng Huang, Kairong Xu, Danhong Ru, Huangyao Front Med (Lausanne) Medicine BACKGROUND: This research focused on evaluating the correlation between platelet count and sepsis prognosis, and even the dose-response relationship, in a cohort of American adults. METHOD: Platelet counts were recorded retrospectively after hospitalization for patients admitted to Beth Israel Deaconess Medical Center’s intensive care unit between 2008 and 2019. On admission to the intensive care unit, sepsis patients were divided into four categories based on platelet counts (very low < 50 × 10(9)/L, intermediate-low 50 × 10(9)–100 × 10(9)/L, low 100 × 10(9)–150 × 10(9)/L, and normal ≥ 150 × 10(9)/L). A multivariate Cox proportional risk model was used to calculate the 28-day risk of mortality in sepsis based on baseline platelet counts, and a two-piece linear regression model was used to calculate the threshold effect. RESULTS: The risk of 28-day septic mortality was nearly 2-fold higher in the platelet very low group when compared to the low group (hazard ratios [HRs], 2.24; 95% confidence interval [CI], 1.92–2.6). Further analysis revealed a curvilinear association between platelets and the sepsis risk of death, with a saturation effect predicted at 100 × 10(9)/L. When platelet counts were below 100 × 10(9)/L, the risk of sepsis 28-day death decreased significantly with increasing platelet count levels (HR, 0.875; 95% CI, 0.84–0.90). CONCLUSION: When platelet count was less than 100 × 10(9)/L, it was a strong predictor of the potential risk of sepsis death, which is declined by 13% for every 10 × 10(9)/L growth in platelets. When platelet counts reach up to 100 × 10(9)/L, the probability of dying to sepsis within 28 days climbs by 1% for every 10 × 10(9)/L increase in platelet count. Frontiers Media S.A. 2022-04-07 /pmc/articles/PMC9021789/ /pubmed/35463034 http://dx.doi.org/10.3389/fmed.2022.833996 Text en Copyright © 2022 Wang, Wang, Wu, Gao, Huang, Xu and Ru. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Wang, Danni
Wang, Suning
Wu, Hao
Gao, Jiansheng
Huang, Kairong
Xu, Danhong
Ru, Huangyao
Association Between Platelet Levels and 28-Day Mortality in Patients With Sepsis: A Retrospective Analysis of a Large Clinical Database MIMIC-IV
title Association Between Platelet Levels and 28-Day Mortality in Patients With Sepsis: A Retrospective Analysis of a Large Clinical Database MIMIC-IV
title_full Association Between Platelet Levels and 28-Day Mortality in Patients With Sepsis: A Retrospective Analysis of a Large Clinical Database MIMIC-IV
title_fullStr Association Between Platelet Levels and 28-Day Mortality in Patients With Sepsis: A Retrospective Analysis of a Large Clinical Database MIMIC-IV
title_full_unstemmed Association Between Platelet Levels and 28-Day Mortality in Patients With Sepsis: A Retrospective Analysis of a Large Clinical Database MIMIC-IV
title_short Association Between Platelet Levels and 28-Day Mortality in Patients With Sepsis: A Retrospective Analysis of a Large Clinical Database MIMIC-IV
title_sort association between platelet levels and 28-day mortality in patients with sepsis: a retrospective analysis of a large clinical database mimic-iv
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021789/
https://www.ncbi.nlm.nih.gov/pubmed/35463034
http://dx.doi.org/10.3389/fmed.2022.833996
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