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Relationship Between Vitamin D Level and Platelet Parameters in Children With Viral Respiratory Infections
Apart from their classical roles, both platelets and vitamin D play important roles in inflammation and infectious diseases. This study evaluated the platelet response to viral respiratory tract infection in children aged 4–16 years, 32 with influenza, 27 with non-influenza viral infection tested by...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021877/ https://www.ncbi.nlm.nih.gov/pubmed/35463888 http://dx.doi.org/10.3389/fped.2022.824959 |
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author | Feketea, Gavriela Vlacha, Vasiliki Pop, Raluca Maria Bocsan, Ioana Corina Stanciu, Luminita Aurelia Buzoianu, Anca Dana Zdrenghea, Mihnea |
author_facet | Feketea, Gavriela Vlacha, Vasiliki Pop, Raluca Maria Bocsan, Ioana Corina Stanciu, Luminita Aurelia Buzoianu, Anca Dana Zdrenghea, Mihnea |
author_sort | Feketea, Gavriela |
collection | PubMed |
description | Apart from their classical roles, both platelets and vitamin D play important roles in inflammation and infectious diseases. This study evaluated the platelet response to viral respiratory tract infection in children aged 4–16 years, 32 with influenza, 27 with non-influenza viral infection tested by nasopharyngeal swab and 21 healthy children of the same age. Blood count, including platelet count (PLT), mean platelet volume (MPV) and other platelet indices, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and vitamin D (vit D) levels were compared. The influenza group showed lower PLT and platelet mass (PLT(*)MPV), and the non-influenza group showed significantly lower MPV, which was correlated with the vit D levels, but not CRP or ESR, and the value vit D(*)MPV was significantly lower in this group. These results revealed that platelet activation in viral respiratory tract infections in children, as measured by MPV, is related to the vit D level, with differences between influenza and non-influenza infection. CONCLUSIONS: Viral respiratory tract infection in children can diminish the platelet size most likely by suppressing the platelet activation. This response is associated with low levels of vit D. Whether the vit D status is associated with the virus-platelet immune/inflammatory process needs further investigation. |
format | Online Article Text |
id | pubmed-9021877 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90218772022-04-22 Relationship Between Vitamin D Level and Platelet Parameters in Children With Viral Respiratory Infections Feketea, Gavriela Vlacha, Vasiliki Pop, Raluca Maria Bocsan, Ioana Corina Stanciu, Luminita Aurelia Buzoianu, Anca Dana Zdrenghea, Mihnea Front Pediatr Pediatrics Apart from their classical roles, both platelets and vitamin D play important roles in inflammation and infectious diseases. This study evaluated the platelet response to viral respiratory tract infection in children aged 4–16 years, 32 with influenza, 27 with non-influenza viral infection tested by nasopharyngeal swab and 21 healthy children of the same age. Blood count, including platelet count (PLT), mean platelet volume (MPV) and other platelet indices, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and vitamin D (vit D) levels were compared. The influenza group showed lower PLT and platelet mass (PLT(*)MPV), and the non-influenza group showed significantly lower MPV, which was correlated with the vit D levels, but not CRP or ESR, and the value vit D(*)MPV was significantly lower in this group. These results revealed that platelet activation in viral respiratory tract infections in children, as measured by MPV, is related to the vit D level, with differences between influenza and non-influenza infection. CONCLUSIONS: Viral respiratory tract infection in children can diminish the platelet size most likely by suppressing the platelet activation. This response is associated with low levels of vit D. Whether the vit D status is associated with the virus-platelet immune/inflammatory process needs further investigation. Frontiers Media S.A. 2022-04-07 /pmc/articles/PMC9021877/ /pubmed/35463888 http://dx.doi.org/10.3389/fped.2022.824959 Text en Copyright © 2022 Feketea, Vlacha, Pop, Bocsan, Stanciu, Buzoianu and Zdrenghea. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Feketea, Gavriela Vlacha, Vasiliki Pop, Raluca Maria Bocsan, Ioana Corina Stanciu, Luminita Aurelia Buzoianu, Anca Dana Zdrenghea, Mihnea Relationship Between Vitamin D Level and Platelet Parameters in Children With Viral Respiratory Infections |
title | Relationship Between Vitamin D Level and Platelet Parameters in Children With Viral Respiratory Infections |
title_full | Relationship Between Vitamin D Level and Platelet Parameters in Children With Viral Respiratory Infections |
title_fullStr | Relationship Between Vitamin D Level and Platelet Parameters in Children With Viral Respiratory Infections |
title_full_unstemmed | Relationship Between Vitamin D Level and Platelet Parameters in Children With Viral Respiratory Infections |
title_short | Relationship Between Vitamin D Level and Platelet Parameters in Children With Viral Respiratory Infections |
title_sort | relationship between vitamin d level and platelet parameters in children with viral respiratory infections |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021877/ https://www.ncbi.nlm.nih.gov/pubmed/35463888 http://dx.doi.org/10.3389/fped.2022.824959 |
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