‘C-type’ closed state and gating mechanisms of K2P channels revealed by conformational changes of the TREK-1 channel

Two-pore domain potassium (K2P) channels gate primarily within the selectivity filter, termed ‘C-type’ gating. Due to the lack of structural insights into the nonconductive (closed) state, ‘C-type’ gating mechanisms remain elusive. Here, molecular dynamics (MD) simulations on TREK-1, a K2P channel,...

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Detalles Bibliográficos
Autores principales: Zhang, Qiansen, Fu, Jie, Zhang, Shaoying, Guo, Peipei, Liu, Shijie, Shen, Juwen, Guo, Jiangtao, Yang, Huaiyu, Yao, Xuebiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9021975/
https://www.ncbi.nlm.nih.gov/pubmed/35022758
http://dx.doi.org/10.1093/jmcb/mjac002

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