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“Sugar-Sweetened Beverages” Is an Independent Risk From Pancreatic Cancer: Based on Half a Million Asian Cohort Followed for 25 Years

Although the link between sugar-sweetened beverages (SSB) and pancreatic cancer has been suggested for its insulin-stimulating connection, most epidemiological studies showed inconclusive relationship. Whether the result was limited by sample size is explored. This prospective study followed 491,929...

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Autores principales: Chen, Chien Hua, Tsai, Min Kuang, Lee, June Han, Lin, Ro-Ting, Hsu, Chung Y., Wen, Christopher, Wu, Xifeng, Chu, Ta-Wei, Wen, Chi Pang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022008/
https://www.ncbi.nlm.nih.gov/pubmed/35463371
http://dx.doi.org/10.3389/fonc.2022.835901
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author Chen, Chien Hua
Tsai, Min Kuang
Lee, June Han
Lin, Ro-Ting
Hsu, Chung Y.
Wen, Christopher
Wu, Xifeng
Chu, Ta-Wei
Wen, Chi Pang
author_facet Chen, Chien Hua
Tsai, Min Kuang
Lee, June Han
Lin, Ro-Ting
Hsu, Chung Y.
Wen, Christopher
Wu, Xifeng
Chu, Ta-Wei
Wen, Chi Pang
author_sort Chen, Chien Hua
collection PubMed
description Although the link between sugar-sweetened beverages (SSB) and pancreatic cancer has been suggested for its insulin-stimulating connection, most epidemiological studies showed inconclusive relationship. Whether the result was limited by sample size is explored. This prospective study followed 491,929 adults, consisting of 235,427 men and 256,502 women (mean age: 39.9, standard deviation: 13.2), from a health surveillance program and there were 523 pancreatic cancer deaths between 1994 and 2017. The individual identification numbers of the cohort were matched with the National Death file for mortality, and Cox models were used to assess the risk. The amount of SSB intake was recorded based on the average consumption in the month before interview by a structured questionnaire. We classified the amount of SSB intake into 4 categories: 0–<0.5 serving/day, ≥0.5–<1 serving per day, ≥1–<2 servings per day, and ≥2 servings per day. One serving was defined as equivalent to 12 oz and contained 35 g added sugar. We used the age and the variables at cohort enrolment as the reported risks of pancreatic cancers. The cohort was divided into 3 age groups, 20–39, 40–59, and ≥60. We found young people (age <40) had higher prevalence and frequency of sugar-sweetened beverages than the elderly. Those consuming 2 servings/day had a 50% increase in pancreatic cancer mortality (HR = 1.55, 95% CI: 1.08–2.24) for the total cohort, but a 3-fold increase (HR: 3.09, 95% CI: 1.44–6.62) for the young. The risk started at 1 serving every other day, with a dose–response relationship. The association of SSB intake of ≥2 servings/day with pancreatic cancer mortality among the total cohort remained significant after excluding those who smoke or have diabetes (HR: 2.12, 97% CI: 1.26–3.57), are obese (HR: 1.57, 95% CI: 1.08–2.30), have hypertension (HR: 1.90, 95% CI: 1.20–3.00), or excluding who died within 3 years after enrollment (HR: 1.67, 95% CI: 1.15–2.45). Risks remained in the sensitivity analyses, implying its independent nature. We concluded that frequent drinking of SSB increased pancreatic cancer in adults, with highest risk among young people.
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spelling pubmed-90220082022-04-22 “Sugar-Sweetened Beverages” Is an Independent Risk From Pancreatic Cancer: Based on Half a Million Asian Cohort Followed for 25 Years Chen, Chien Hua Tsai, Min Kuang Lee, June Han Lin, Ro-Ting Hsu, Chung Y. Wen, Christopher Wu, Xifeng Chu, Ta-Wei Wen, Chi Pang Front Oncol Oncology Although the link between sugar-sweetened beverages (SSB) and pancreatic cancer has been suggested for its insulin-stimulating connection, most epidemiological studies showed inconclusive relationship. Whether the result was limited by sample size is explored. This prospective study followed 491,929 adults, consisting of 235,427 men and 256,502 women (mean age: 39.9, standard deviation: 13.2), from a health surveillance program and there were 523 pancreatic cancer deaths between 1994 and 2017. The individual identification numbers of the cohort were matched with the National Death file for mortality, and Cox models were used to assess the risk. The amount of SSB intake was recorded based on the average consumption in the month before interview by a structured questionnaire. We classified the amount of SSB intake into 4 categories: 0–<0.5 serving/day, ≥0.5–<1 serving per day, ≥1–<2 servings per day, and ≥2 servings per day. One serving was defined as equivalent to 12 oz and contained 35 g added sugar. We used the age and the variables at cohort enrolment as the reported risks of pancreatic cancers. The cohort was divided into 3 age groups, 20–39, 40–59, and ≥60. We found young people (age <40) had higher prevalence and frequency of sugar-sweetened beverages than the elderly. Those consuming 2 servings/day had a 50% increase in pancreatic cancer mortality (HR = 1.55, 95% CI: 1.08–2.24) for the total cohort, but a 3-fold increase (HR: 3.09, 95% CI: 1.44–6.62) for the young. The risk started at 1 serving every other day, with a dose–response relationship. The association of SSB intake of ≥2 servings/day with pancreatic cancer mortality among the total cohort remained significant after excluding those who smoke or have diabetes (HR: 2.12, 97% CI: 1.26–3.57), are obese (HR: 1.57, 95% CI: 1.08–2.30), have hypertension (HR: 1.90, 95% CI: 1.20–3.00), or excluding who died within 3 years after enrollment (HR: 1.67, 95% CI: 1.15–2.45). Risks remained in the sensitivity analyses, implying its independent nature. We concluded that frequent drinking of SSB increased pancreatic cancer in adults, with highest risk among young people. Frontiers Media S.A. 2022-04-07 /pmc/articles/PMC9022008/ /pubmed/35463371 http://dx.doi.org/10.3389/fonc.2022.835901 Text en Copyright © 2022 Chen, Tsai, Lee, Lin, Hsu, Wen, Wu, Chu and Wen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Chen, Chien Hua
Tsai, Min Kuang
Lee, June Han
Lin, Ro-Ting
Hsu, Chung Y.
Wen, Christopher
Wu, Xifeng
Chu, Ta-Wei
Wen, Chi Pang
“Sugar-Sweetened Beverages” Is an Independent Risk From Pancreatic Cancer: Based on Half a Million Asian Cohort Followed for 25 Years
title “Sugar-Sweetened Beverages” Is an Independent Risk From Pancreatic Cancer: Based on Half a Million Asian Cohort Followed for 25 Years
title_full “Sugar-Sweetened Beverages” Is an Independent Risk From Pancreatic Cancer: Based on Half a Million Asian Cohort Followed for 25 Years
title_fullStr “Sugar-Sweetened Beverages” Is an Independent Risk From Pancreatic Cancer: Based on Half a Million Asian Cohort Followed for 25 Years
title_full_unstemmed “Sugar-Sweetened Beverages” Is an Independent Risk From Pancreatic Cancer: Based on Half a Million Asian Cohort Followed for 25 Years
title_short “Sugar-Sweetened Beverages” Is an Independent Risk From Pancreatic Cancer: Based on Half a Million Asian Cohort Followed for 25 Years
title_sort “sugar-sweetened beverages” is an independent risk from pancreatic cancer: based on half a million asian cohort followed for 25 years
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022008/
https://www.ncbi.nlm.nih.gov/pubmed/35463371
http://dx.doi.org/10.3389/fonc.2022.835901
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