ACE2 immunohistochemistry in salivary and tracheal glands related to age

OBJECTIVE: SARS-CoV-2 is the cause of COVID-19, the rapidly spreading pandemic. When SARS-CoV-2 enters the target cells in the respiratory system, the spike glycoprotein binds to a cellular receptor angiotensin converting enzyme 2 (ACE2). The susceptibility to infection in individuals under 20 years...

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Autores principales: Nogami, Makoto, Hoshi, Tomoaki, Toukairin, Yoko, Arai, Tomomi, Nishio, Tadashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022160/
https://www.ncbi.nlm.nih.gov/pubmed/35449115
http://dx.doi.org/10.1186/s13104-022-06031-1
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author Nogami, Makoto
Hoshi, Tomoaki
Toukairin, Yoko
Arai, Tomomi
Nishio, Tadashi
author_facet Nogami, Makoto
Hoshi, Tomoaki
Toukairin, Yoko
Arai, Tomomi
Nishio, Tadashi
author_sort Nogami, Makoto
collection PubMed
description OBJECTIVE: SARS-CoV-2 is the cause of COVID-19, the rapidly spreading pandemic. When SARS-CoV-2 enters the target cells in the respiratory system, the spike glycoprotein binds to a cellular receptor angiotensin converting enzyme 2 (ACE2). The susceptibility to infection in individuals under 20 years of age is approximately half that of adults aged over 20 years. In this study, we investigated the immunohistochemical protein expressions of ACE2 in mandibular salivary glands and tracheal glands from forensic autopsy specimens covering adults and children. RESULTS: The ACE2 immunohistochemistry of autopsy specimens was performed, and the percentages of the immuno-positive areas in the cell layers of the glands were calculated. Our results demonstrate that the ACE2 positivity in mandibular salivary gland and tracheal glands showed the statistically significant decrease with the increase of age, which indicates that the susceptibility of aged individuals to SARS-CoV-2 may be due to various factors including but not limited to ACE2 protein expressions.
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spelling pubmed-90221602022-04-21 ACE2 immunohistochemistry in salivary and tracheal glands related to age Nogami, Makoto Hoshi, Tomoaki Toukairin, Yoko Arai, Tomomi Nishio, Tadashi BMC Res Notes Research Note OBJECTIVE: SARS-CoV-2 is the cause of COVID-19, the rapidly spreading pandemic. When SARS-CoV-2 enters the target cells in the respiratory system, the spike glycoprotein binds to a cellular receptor angiotensin converting enzyme 2 (ACE2). The susceptibility to infection in individuals under 20 years of age is approximately half that of adults aged over 20 years. In this study, we investigated the immunohistochemical protein expressions of ACE2 in mandibular salivary glands and tracheal glands from forensic autopsy specimens covering adults and children. RESULTS: The ACE2 immunohistochemistry of autopsy specimens was performed, and the percentages of the immuno-positive areas in the cell layers of the glands were calculated. Our results demonstrate that the ACE2 positivity in mandibular salivary gland and tracheal glands showed the statistically significant decrease with the increase of age, which indicates that the susceptibility of aged individuals to SARS-CoV-2 may be due to various factors including but not limited to ACE2 protein expressions. BioMed Central 2022-04-21 /pmc/articles/PMC9022160/ /pubmed/35449115 http://dx.doi.org/10.1186/s13104-022-06031-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Note
Nogami, Makoto
Hoshi, Tomoaki
Toukairin, Yoko
Arai, Tomomi
Nishio, Tadashi
ACE2 immunohistochemistry in salivary and tracheal glands related to age
title ACE2 immunohistochemistry in salivary and tracheal glands related to age
title_full ACE2 immunohistochemistry in salivary and tracheal glands related to age
title_fullStr ACE2 immunohistochemistry in salivary and tracheal glands related to age
title_full_unstemmed ACE2 immunohistochemistry in salivary and tracheal glands related to age
title_short ACE2 immunohistochemistry in salivary and tracheal glands related to age
title_sort ace2 immunohistochemistry in salivary and tracheal glands related to age
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022160/
https://www.ncbi.nlm.nih.gov/pubmed/35449115
http://dx.doi.org/10.1186/s13104-022-06031-1
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AT araitomomi ace2immunohistochemistryinsalivaryandtrachealglandsrelatedtoage
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