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CDK/cyclin dependencies define extreme cancer cell-cycle heterogeneity and collateral vulnerabilities

Progression through G1/S phase of the cell cycle is coordinated by cyclin-dependent kinase (CDK) activities. Here, we find that the requirement for different CDK activities and cyclins in driving cancer cell cycles is highly heterogeneous. The differential gene requirements associate with tumor orig...

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Detalles Bibliográficos
Autores principales:	Knudsen, Erik S., Kumarasamy, Vishnu, Nambiar, Ram, Pearson, Joel D., Vail, Paris, Rosenheck, Hanna, Wang, Jianxin, Eng, Kevin, Bremner, Rod, Schramek, Daniel, Rubin, Seth M., Welm, Alana L., Witkiewicz, Agnieszka K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022184/ https://www.ncbi.nlm.nih.gov/pubmed/35235778 http://dx.doi.org/10.1016/j.celrep.2022.110448

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