Large 1p36 Deletions Affecting Arid1a Locus Facilitate Mycn-Driven Oncogenesis in Neuroblastoma

Loss of heterozygosity (LOH) at 1p36 occurs in multiple cancers, including neuroblastoma (NBL). MYCN amplification and 1p36 deletions tightly correlate with markers of tumor aggressiveness in NBL. Although distal 1p36 losses associate with single-copy MYCN tumors, larger deletions correlate with MYC...

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Detalles Bibliográficos
Autores principales: García-López, Jesus, Wallace, Kirby, Otero, Joel H., Olsen, Rachelle, Wang, Yong-dong, Finkelstein, David, Gudenas, Brian L., Rehg, Jerold E., Northcott, Paul, Davidoff, Andrew M., Freeman, Kevin W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022217/
https://www.ncbi.nlm.nih.gov/pubmed/31940489
http://dx.doi.org/10.1016/j.celrep.2019.12.048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022217/
https://www.ncbi.nlm.nih.gov/pubmed/31940489
http://dx.doi.org/10.1016/j.celrep.2019.12.048

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