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Induction of Paraptosis by Cyclometalated Iridium Complex-Peptide Hybrids and CGP37157 via a Mitochondrial Ca(2+) Overload Triggered by Membrane Fusion between Mitochondria and the Endoplasmic Reticulum

[Image: see text] We previously reported that a cyclometalated iridium (Ir) complex-peptide hybrid (IPH) 4 functionalized with a cationic KKKGG peptide unit on the 2-phenylpyridine ligand induces paraptosis, a relatively newly found programmed cell death, in cancer cells (Jurkat cells) via the direc...

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Detalles Bibliográficos
Autores principales:	Yokoi, Kenta, Yamaguchi, Kohei, Umezawa, Masakazu, Tsuchiya, Koji, Aoki, Shin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022229/ https://www.ncbi.nlm.nih.gov/pubmed/35363482 http://dx.doi.org/10.1021/acs.biochem.2c00061

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