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Antidiabetic and antihyperlipidemic effects of Premna spinosa bark in experimental animal models
The purpose of the study is to evaluate the antidiabetic and hyperlipidemic potential of stem bark extract of Premna spinosa (Lamiaceae), by using streptozotocin (STZ)-nicotinamide (NA)-induced diabetic and triton-induced hyperlipidemic models in albino rats. The blood glucose, total cholesterol, an...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022364/ https://www.ncbi.nlm.nih.gov/pubmed/35464654 http://dx.doi.org/10.4103/japtr.japtr_300_21 |
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author | Rout, Rama Chandra Panda, Prasanna Kumar Behera, Lelin Panda, Santosh Kumar Pattnaik, Gurudutta Bhattacharya, Sanjib Kar, Biswakanth |
author_facet | Rout, Rama Chandra Panda, Prasanna Kumar Behera, Lelin Panda, Santosh Kumar Pattnaik, Gurudutta Bhattacharya, Sanjib Kar, Biswakanth |
author_sort | Rout, Rama Chandra |
collection | PubMed |
description | The purpose of the study is to evaluate the antidiabetic and hyperlipidemic potential of stem bark extract of Premna spinosa (Lamiaceae), by using streptozotocin (STZ)-nicotinamide (NA)-induced diabetic and triton-induced hyperlipidemic models in albino rats. The blood glucose, total cholesterol, and triglyceride levels were determined in STZ-NA-induced diabetic and triton-induced hyperlipidemic rats, as per the respective protocols. It was found that there is the dose dependent and significant reduction in foregoing parameters on the administration of extract from Premna spinosa stem bark at the doses of 200, 400, and 800 mg/kg body weight to diabetic and hyperlipidemic rats. From these observed results it may be inferred that the stem bark of Premna spinosa possesses remarkable antidiabetic and antihyperlipidemic properties. |
format | Online Article Text |
id | pubmed-9022364 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-90223642022-04-22 Antidiabetic and antihyperlipidemic effects of Premna spinosa bark in experimental animal models Rout, Rama Chandra Panda, Prasanna Kumar Behera, Lelin Panda, Santosh Kumar Pattnaik, Gurudutta Bhattacharya, Sanjib Kar, Biswakanth J Adv Pharm Technol Res Original Article The purpose of the study is to evaluate the antidiabetic and hyperlipidemic potential of stem bark extract of Premna spinosa (Lamiaceae), by using streptozotocin (STZ)-nicotinamide (NA)-induced diabetic and triton-induced hyperlipidemic models in albino rats. The blood glucose, total cholesterol, and triglyceride levels were determined in STZ-NA-induced diabetic and triton-induced hyperlipidemic rats, as per the respective protocols. It was found that there is the dose dependent and significant reduction in foregoing parameters on the administration of extract from Premna spinosa stem bark at the doses of 200, 400, and 800 mg/kg body weight to diabetic and hyperlipidemic rats. From these observed results it may be inferred that the stem bark of Premna spinosa possesses remarkable antidiabetic and antihyperlipidemic properties. Wolters Kluwer - Medknow 2022 2022-04-07 /pmc/articles/PMC9022364/ /pubmed/35464654 http://dx.doi.org/10.4103/japtr.japtr_300_21 Text en Copyright: © 2022 Journal of Advanced Pharmaceutical Technology & Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Rout, Rama Chandra Panda, Prasanna Kumar Behera, Lelin Panda, Santosh Kumar Pattnaik, Gurudutta Bhattacharya, Sanjib Kar, Biswakanth Antidiabetic and antihyperlipidemic effects of Premna spinosa bark in experimental animal models |
title | Antidiabetic and antihyperlipidemic effects of Premna spinosa bark in experimental animal models |
title_full | Antidiabetic and antihyperlipidemic effects of Premna spinosa bark in experimental animal models |
title_fullStr | Antidiabetic and antihyperlipidemic effects of Premna spinosa bark in experimental animal models |
title_full_unstemmed | Antidiabetic and antihyperlipidemic effects of Premna spinosa bark in experimental animal models |
title_short | Antidiabetic and antihyperlipidemic effects of Premna spinosa bark in experimental animal models |
title_sort | antidiabetic and antihyperlipidemic effects of premna spinosa bark in experimental animal models |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022364/ https://www.ncbi.nlm.nih.gov/pubmed/35464654 http://dx.doi.org/10.4103/japtr.japtr_300_21 |
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