Cargando…

Immunogenicity of BNT162b2 vaccine booster against SARS-CoV-2 Delta and Omicron variants in nursing home residents: A prospective observational study in older adults aged from 68 to 98 years

BACKGROUND: The present study aimed to evaluate the persistent immunogenicity offered by a third dose of BNT162b2 against Delta and Omicron variants, in nursing home (NH) residents. METHODS: In this monocenter prospective observational study, anti-spike IgG levels, S1 domain reactive T cell counts,...

Descripción completa

Detalles Bibliográficos
Autores principales: Alidjinou, Enagnon Kazali, Demaret, Julie, Corroyer-Simovic, Bénédicte, Labreuche, Julien, Goffard, Anne, Trauet, Jacques, Lupau, Daniela, Miczek, Sophie, Vuotto, Fanny, Dendooven, Arnaud, Huvent-Grelle, Dominique, Podvin, Juliette, Dreuil, Daniel, Faure, Karine, Deplanque, Dominique, Bocket, Laurence, Duhamel, Alain, Sobaszek, Annie, Hober, Didier, Hisbergues, Michael, Puisieux, Francois, Autran, Brigitte, Yazdanpanah, Yazdan, Labalette, Myriam, Lefèvre, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022478/
https://www.ncbi.nlm.nih.gov/pubmed/35469147
http://dx.doi.org/10.1016/j.lanepe.2022.100385
Descripción
Sumario:BACKGROUND: The present study aimed to evaluate the persistent immunogenicity offered by a third dose of BNT162b2 against Delta and Omicron variants, in nursing home (NH) residents. METHODS: In this monocenter prospective observational study, anti-spike IgG levels, S1 domain reactive T cell counts, serum neutralizing antibody titers against Delta and Omicron variants were compared before and up to three months after the BNT162b2 booster dose, in NH residents without COVID-19 (COVID-19 naive) or with COVID-19 prior to initial vaccination (COVID-19 recovered). FINDINGS: 106 NH residents (median [interquartile range] age: 86·5 [81;91] years) were included. The booster dose induced a high increase of anti-spike antibody levels in all subjects (p < 0.0001) and a mild transient increase of specific T cells. Before the booster dose, Delta neutralization was detected in 19% (n = 8/43) and 88% (n = 37/42) of COVID-19 naive and COVID-19 recovered subjects, respectively. Three months after the booster dose, all NH residents developed and maintained a higher Delta neutralization (p < 0·0001). Before the booster dose, Omicron neutralization was detected in 5% (n = 2/43) and 55% (n = 23/42) of COVID-19 naive and COVID-19 recovered subjects, respectively, and three months after, in 84% and 95%, respectively. Neutralizing titers to Omicron were lower than to Delta in both groups with a 35-fold reduction compared to Delta. INTERPRETATION: The booster dose restores high neutralization titers against Delta in all NH residents, and at a lower level against Omicron in a large majority of participants. Future studies are warranted to assess if repeated BNT162b2 booster doses or new specific vaccines might be considered for protecting such fragile patients against Omicron and/or future SARS-CoV-2 variants. FUNDING: French government through the Programme Investissement d'Avenir (I-SITE ULNE/ANR-16-IDEX-0004 ULNE) and the Label of COVID-19 National Research Priority (National Steering Committee on Therapeutic Trials and Other COVID-19 Research, CAPNET).