Draft Genome Sequences of Sixteen Fluoroquinolone-Resistant Extraintestinal Escherichia coli Isolates from Human Patients

We report here the draft genome sequences of 16 fluoroquinolone-resistant extraintestinal Escherichia coli isolates from human patients. These isolates had high MICs (32 to 256 μg/mL) for ciprofloxacin and contained point mutations in the quinolone resistance-determining region (QRDR) of both gyrA a...

Descripción completa

Detalles Bibliográficos
Autores principales: Alotaibi, Khulud, Khan, Ashraf A., Marasa, Bernard, Khan, Saeed A., Johnson, James, Johnston, Brian, Sung, Kidon, Nawaz, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Genome Sequences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022563/
https://www.ncbi.nlm.nih.gov/pubmed/35289649
http://dx.doi.org/10.1128/mra.00003-22
_version_ 1784690113184268288
author Alotaibi, Khulud
Khan, Ashraf A.
Marasa, Bernard
Khan, Saeed A.
Johnson, James
Johnston, Brian
Sung, Kidon
Nawaz, Mohamed
author_facet Alotaibi, Khulud
Khan, Ashraf A.
Marasa, Bernard
Khan, Saeed A.
Johnson, James
Johnston, Brian
Sung, Kidon
Nawaz, Mohamed
author_sort Alotaibi, Khulud
collection PubMed
description We report here the draft genome sequences of 16 fluoroquinolone-resistant extraintestinal Escherichia coli isolates from human patients. These isolates had high MICs (32 to 256 μg/mL) for ciprofloxacin and contained point mutations in the quinolone resistance-determining region (QRDR) of both gyrA and parC that confer resistance to fluoroquinolone. The whole-genome sequence data provide a better understanding of the fluoroquinolone resistance mechanisms in these isolates and would be beneficial in source tracking these pathogens during pandemic outbreaks.
format Online
Article
Text
id pubmed-9022563
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher American Society for Microbiology
record_format MEDLINE/PubMed
spelling pubmed-90225632022-04-22 Draft Genome Sequences of Sixteen Fluoroquinolone-Resistant Extraintestinal Escherichia coli Isolates from Human Patients Alotaibi, Khulud Khan, Ashraf A. Marasa, Bernard Khan, Saeed A. Johnson, James Johnston, Brian Sung, Kidon Nawaz, Mohamed Microbiol Resour Announc Genome Sequences We report here the draft genome sequences of 16 fluoroquinolone-resistant extraintestinal Escherichia coli isolates from human patients. These isolates had high MICs (32 to 256 μg/mL) for ciprofloxacin and contained point mutations in the quinolone resistance-determining region (QRDR) of both gyrA and parC that confer resistance to fluoroquinolone. The whole-genome sequence data provide a better understanding of the fluoroquinolone resistance mechanisms in these isolates and would be beneficial in source tracking these pathogens during pandemic outbreaks. American Society for Microbiology 2022-03-15 /pmc/articles/PMC9022563/ /pubmed/35289649 http://dx.doi.org/10.1128/mra.00003-22 Text en https://doi.org/10.1128/AuthorWarrantyLicense.v1This is a work of the U.S. Government and is not subject to copyright protection in the United States. Foreign copyrights may apply.
spellingShingle Genome Sequences
Alotaibi, Khulud
Khan, Ashraf A.
Marasa, Bernard
Khan, Saeed A.
Johnson, James
Johnston, Brian
Sung, Kidon
Nawaz, Mohamed
Draft Genome Sequences of Sixteen Fluoroquinolone-Resistant Extraintestinal Escherichia coli Isolates from Human Patients
title Draft Genome Sequences of Sixteen Fluoroquinolone-Resistant Extraintestinal Escherichia coli Isolates from Human Patients
title_full Draft Genome Sequences of Sixteen Fluoroquinolone-Resistant Extraintestinal Escherichia coli Isolates from Human Patients
title_fullStr Draft Genome Sequences of Sixteen Fluoroquinolone-Resistant Extraintestinal Escherichia coli Isolates from Human Patients
title_full_unstemmed Draft Genome Sequences of Sixteen Fluoroquinolone-Resistant Extraintestinal Escherichia coli Isolates from Human Patients
title_short Draft Genome Sequences of Sixteen Fluoroquinolone-Resistant Extraintestinal Escherichia coli Isolates from Human Patients
title_sort draft genome sequences of sixteen fluoroquinolone-resistant extraintestinal escherichia coli isolates from human patients
topic Genome Sequences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022563/
https://www.ncbi.nlm.nih.gov/pubmed/35289649
http://dx.doi.org/10.1128/mra.00003-22
work_keys_str_mv AT alotaibikhulud draftgenomesequencesofsixteenfluoroquinoloneresistantextraintestinalescherichiacoliisolatesfromhumanpatients
AT khanashrafa draftgenomesequencesofsixteenfluoroquinoloneresistantextraintestinalescherichiacoliisolatesfromhumanpatients
AT marasabernard draftgenomesequencesofsixteenfluoroquinoloneresistantextraintestinalescherichiacoliisolatesfromhumanpatients
AT khansaeeda draftgenomesequencesofsixteenfluoroquinoloneresistantextraintestinalescherichiacoliisolatesfromhumanpatients
AT johnsonjames draftgenomesequencesofsixteenfluoroquinoloneresistantextraintestinalescherichiacoliisolatesfromhumanpatients
AT johnstonbrian draftgenomesequencesofsixteenfluoroquinoloneresistantextraintestinalescherichiacoliisolatesfromhumanpatients
AT sungkidon draftgenomesequencesofsixteenfluoroquinoloneresistantextraintestinalescherichiacoliisolatesfromhumanpatients
AT nawazmohamed draftgenomesequencesofsixteenfluoroquinoloneresistantextraintestinalescherichiacoliisolatesfromhumanpatients

Ejemplares similares