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A Neuroanatomy of Positive Affect Display – Subcortical Fiber Pathways Relevant for Initiation and Modulation of Smiling and Laughing

BACKGROUND: We here report two cases of stimulation induced pathological laughter (PL) under thalamic deep brain stimulation (DBS) for essential tremor and interpret the effects based on a modified neuroanatomy of positive affect display (PAD). OBJECTIVE/HYPOTHESIS: The hitherto existing neuroanatom...

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Autores principales: Coenen, Volker A., Sajonz, Bastian E. A., Hurwitz, Trevor A., Böck, Marlies, Hosp, Jonas A., Reinacher, Peter C., Urbach, Horst, Blazhenets, Ganna, Meyer, Philipp T., Reisert, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022623/
https://www.ncbi.nlm.nih.gov/pubmed/35464145
http://dx.doi.org/10.3389/fnbeh.2022.817554
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author Coenen, Volker A.
Sajonz, Bastian E. A.
Hurwitz, Trevor A.
Böck, Marlies
Hosp, Jonas A.
Reinacher, Peter C.
Urbach, Horst
Blazhenets, Ganna
Meyer, Philipp T.
Reisert, Marco
author_facet Coenen, Volker A.
Sajonz, Bastian E. A.
Hurwitz, Trevor A.
Böck, Marlies
Hosp, Jonas A.
Reinacher, Peter C.
Urbach, Horst
Blazhenets, Ganna
Meyer, Philipp T.
Reisert, Marco
author_sort Coenen, Volker A.
collection PubMed
description BACKGROUND: We here report two cases of stimulation induced pathological laughter (PL) under thalamic deep brain stimulation (DBS) for essential tremor and interpret the effects based on a modified neuroanatomy of positive affect display (PAD). OBJECTIVE/HYPOTHESIS: The hitherto existing neuroanatomy of PAD can be augmented with recently described parts of the motor medial forebrain bundle (motorMFB). We speculate that a co-stimulation of parts of this fiber structure might lead to a non-volitional modulation of PAD resulting in PL. METHODS: We describe the clinical and individual imaging workup and combine the interpretation with normative diffusion tensor imaging (DTI)-tractography descriptions of motor connections of the ventral tegmental area (VTA) (n = 200 subjects, HCP cohort), [[(18)F] fluorodeoxyglucose ((18)FDG)] positron emission tomography (PET), and volume of activated tissue simulations. We integrate these results with literature concerning PAD and the neuroanatomy of smiling and laughing. RESULTS: DBS electrodes bilaterally co-localized with the MB-pathway (“limiter pathway”). The FDG PET activation pattern allowed to explain pathological PAD. A conceptual revised neuroanatomy of PAD is described. CONCLUSION: Eliciting pathological PAD through chronic thalamic DBS is a new finding and has previously not been reported. PAD is evolution driven, hard wired to the brain and realized over previously described branches of the motorMFB. A major relay region is the VTA/mammillary body complex. PAD physiologically undergoes conscious modulation mainly via the MB branch of the motorMFB (limiter). This limiter in our cases is bilaterally disturbed through DBS. The here described anatomy adds to a previously described framework of neuroanatomy of laughter and humor.
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spelling pubmed-90226232022-04-22 A Neuroanatomy of Positive Affect Display – Subcortical Fiber Pathways Relevant for Initiation and Modulation of Smiling and Laughing Coenen, Volker A. Sajonz, Bastian E. A. Hurwitz, Trevor A. Böck, Marlies Hosp, Jonas A. Reinacher, Peter C. Urbach, Horst Blazhenets, Ganna Meyer, Philipp T. Reisert, Marco Front Behav Neurosci Neuroscience BACKGROUND: We here report two cases of stimulation induced pathological laughter (PL) under thalamic deep brain stimulation (DBS) for essential tremor and interpret the effects based on a modified neuroanatomy of positive affect display (PAD). OBJECTIVE/HYPOTHESIS: The hitherto existing neuroanatomy of PAD can be augmented with recently described parts of the motor medial forebrain bundle (motorMFB). We speculate that a co-stimulation of parts of this fiber structure might lead to a non-volitional modulation of PAD resulting in PL. METHODS: We describe the clinical and individual imaging workup and combine the interpretation with normative diffusion tensor imaging (DTI)-tractography descriptions of motor connections of the ventral tegmental area (VTA) (n = 200 subjects, HCP cohort), [[(18)F] fluorodeoxyglucose ((18)FDG)] positron emission tomography (PET), and volume of activated tissue simulations. We integrate these results with literature concerning PAD and the neuroanatomy of smiling and laughing. RESULTS: DBS electrodes bilaterally co-localized with the MB-pathway (“limiter pathway”). The FDG PET activation pattern allowed to explain pathological PAD. A conceptual revised neuroanatomy of PAD is described. CONCLUSION: Eliciting pathological PAD through chronic thalamic DBS is a new finding and has previously not been reported. PAD is evolution driven, hard wired to the brain and realized over previously described branches of the motorMFB. A major relay region is the VTA/mammillary body complex. PAD physiologically undergoes conscious modulation mainly via the MB branch of the motorMFB (limiter). This limiter in our cases is bilaterally disturbed through DBS. The here described anatomy adds to a previously described framework of neuroanatomy of laughter and humor. Frontiers Media S.A. 2022-03-30 /pmc/articles/PMC9022623/ /pubmed/35464145 http://dx.doi.org/10.3389/fnbeh.2022.817554 Text en Copyright © 2022 Coenen, Sajonz, Hurwitz, Böck, Hosp, Reinacher, Urbach, Blazhenets, Meyer and Reisert. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Coenen, Volker A.
Sajonz, Bastian E. A.
Hurwitz, Trevor A.
Böck, Marlies
Hosp, Jonas A.
Reinacher, Peter C.
Urbach, Horst
Blazhenets, Ganna
Meyer, Philipp T.
Reisert, Marco
A Neuroanatomy of Positive Affect Display – Subcortical Fiber Pathways Relevant for Initiation and Modulation of Smiling and Laughing
title A Neuroanatomy of Positive Affect Display – Subcortical Fiber Pathways Relevant for Initiation and Modulation of Smiling and Laughing
title_full A Neuroanatomy of Positive Affect Display – Subcortical Fiber Pathways Relevant for Initiation and Modulation of Smiling and Laughing
title_fullStr A Neuroanatomy of Positive Affect Display – Subcortical Fiber Pathways Relevant for Initiation and Modulation of Smiling and Laughing
title_full_unstemmed A Neuroanatomy of Positive Affect Display – Subcortical Fiber Pathways Relevant for Initiation and Modulation of Smiling and Laughing
title_short A Neuroanatomy of Positive Affect Display – Subcortical Fiber Pathways Relevant for Initiation and Modulation of Smiling and Laughing
title_sort neuroanatomy of positive affect display – subcortical fiber pathways relevant for initiation and modulation of smiling and laughing
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022623/
https://www.ncbi.nlm.nih.gov/pubmed/35464145
http://dx.doi.org/10.3389/fnbeh.2022.817554
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