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The Role of Medial Prefrontal Cortex in Acupuncture Treatment for Functional Dyspepsia

Acupuncture is an effective therapy for functional dyspepsia (FD). However, the efficacy of acupuncture in the treatment of FD varies among individuals in clinical practice. This study aimed to reveal the brain response patterns in acupuncture higher response/lower response FD patients. Firstly, we...

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Autores principales: Teng, Yuke, Yin, Tao, Yang, Yue, Sun, Ruirui, Tian, Zilei, Ma, Peihong, He, Zhaoxuan, Qu, Yuzhu, Huang, Liuyang, Chen, Yuan, Zeng, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022633/
https://www.ncbi.nlm.nih.gov/pubmed/35464313
http://dx.doi.org/10.3389/fnins.2022.801899
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author Teng, Yuke
Yin, Tao
Yang, Yue
Sun, Ruirui
Tian, Zilei
Ma, Peihong
He, Zhaoxuan
Qu, Yuzhu
Huang, Liuyang
Chen, Yuan
Zeng, Fang
author_facet Teng, Yuke
Yin, Tao
Yang, Yue
Sun, Ruirui
Tian, Zilei
Ma, Peihong
He, Zhaoxuan
Qu, Yuzhu
Huang, Liuyang
Chen, Yuan
Zeng, Fang
author_sort Teng, Yuke
collection PubMed
description Acupuncture is an effective therapy for functional dyspepsia (FD). However, the efficacy of acupuncture in the treatment of FD varies among individuals in clinical practice. This study aimed to reveal the brain response patterns in acupuncture higher response/lower response FD patients. Firstly, we performed a within-group comparison of brain function activity before and after acupuncture treatment in 115 FD patients and analyzed the correlation between brain function activity changes and clinical improvements. Secondly, 115 subjects were divided into the acupuncture higher response group or the lower response group based on the median clinical improvement values. The changes in functional brain activity after acupuncture treatment were investigated in these two groups, respectively. Finally, the identified brain regions associated with the clinical improvements were set as regions of interest (ROI), and the ROI-to-voxel functional connectivity comparisons were also performed in both groups, respectively. The results demonstrated that the functional activities of the left cerebellum inferior, right middle temporal gyrus, and right medial prefrontal cortex (mPFC) were increased, and the left Heschl and right middle cingulate cortex were decreased in 115 FD patients after acupuncture treatment. The functional connectivity changes of mPFC were correlated with improving the Nepean Dyspepsia Symptom Index. The significant increase in mPFC functional activity was also found in acupuncture higher response FD patients but not in lower response FD patients. The functional connectivity between the mPFC and default mode network (DMN) was significantly diminished in the higher response group but not in the lower response group. In conclusion, this study suggested that modulating the functional activity of the mPFC and its connectivity to the DMN may be one of the important mechanisms of acupuncture for treating FD with a higher response.
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spelling pubmed-90226332022-04-22 The Role of Medial Prefrontal Cortex in Acupuncture Treatment for Functional Dyspepsia Teng, Yuke Yin, Tao Yang, Yue Sun, Ruirui Tian, Zilei Ma, Peihong He, Zhaoxuan Qu, Yuzhu Huang, Liuyang Chen, Yuan Zeng, Fang Front Neurosci Neuroscience Acupuncture is an effective therapy for functional dyspepsia (FD). However, the efficacy of acupuncture in the treatment of FD varies among individuals in clinical practice. This study aimed to reveal the brain response patterns in acupuncture higher response/lower response FD patients. Firstly, we performed a within-group comparison of brain function activity before and after acupuncture treatment in 115 FD patients and analyzed the correlation between brain function activity changes and clinical improvements. Secondly, 115 subjects were divided into the acupuncture higher response group or the lower response group based on the median clinical improvement values. The changes in functional brain activity after acupuncture treatment were investigated in these two groups, respectively. Finally, the identified brain regions associated with the clinical improvements were set as regions of interest (ROI), and the ROI-to-voxel functional connectivity comparisons were also performed in both groups, respectively. The results demonstrated that the functional activities of the left cerebellum inferior, right middle temporal gyrus, and right medial prefrontal cortex (mPFC) were increased, and the left Heschl and right middle cingulate cortex were decreased in 115 FD patients after acupuncture treatment. The functional connectivity changes of mPFC were correlated with improving the Nepean Dyspepsia Symptom Index. The significant increase in mPFC functional activity was also found in acupuncture higher response FD patients but not in lower response FD patients. The functional connectivity between the mPFC and default mode network (DMN) was significantly diminished in the higher response group but not in the lower response group. In conclusion, this study suggested that modulating the functional activity of the mPFC and its connectivity to the DMN may be one of the important mechanisms of acupuncture for treating FD with a higher response. Frontiers Media S.A. 2022-04-07 /pmc/articles/PMC9022633/ /pubmed/35464313 http://dx.doi.org/10.3389/fnins.2022.801899 Text en Copyright © 2022 Teng, Yin, Yang, Sun, Tian, Ma, He, Qu, Huang, Chen and Zeng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Teng, Yuke
Yin, Tao
Yang, Yue
Sun, Ruirui
Tian, Zilei
Ma, Peihong
He, Zhaoxuan
Qu, Yuzhu
Huang, Liuyang
Chen, Yuan
Zeng, Fang
The Role of Medial Prefrontal Cortex in Acupuncture Treatment for Functional Dyspepsia
title The Role of Medial Prefrontal Cortex in Acupuncture Treatment for Functional Dyspepsia
title_full The Role of Medial Prefrontal Cortex in Acupuncture Treatment for Functional Dyspepsia
title_fullStr The Role of Medial Prefrontal Cortex in Acupuncture Treatment for Functional Dyspepsia
title_full_unstemmed The Role of Medial Prefrontal Cortex in Acupuncture Treatment for Functional Dyspepsia
title_short The Role of Medial Prefrontal Cortex in Acupuncture Treatment for Functional Dyspepsia
title_sort role of medial prefrontal cortex in acupuncture treatment for functional dyspepsia
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022633/
https://www.ncbi.nlm.nih.gov/pubmed/35464313
http://dx.doi.org/10.3389/fnins.2022.801899
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