Cytokine-Mediated Crosstalk Between Keratinocytes and T Cells in Atopic Dermatitis

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by barrier dysfunction, dysregulated immune response, and dysbiosis with increased Staphylococcus aureus colonization. Infiltration of various T helper cell subsets into lesional skin and subsequent cytokine release are a ha...

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Detalles Bibliográficos
Autores principales: Humeau, Mélanie, Boniface, Katia, Bodet, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022745/
https://www.ncbi.nlm.nih.gov/pubmed/35464457
http://dx.doi.org/10.3389/fimmu.2022.801579
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author Humeau, Mélanie
Boniface, Katia
Bodet, Charles
author_facet Humeau, Mélanie
Boniface, Katia
Bodet, Charles
author_sort Humeau, Mélanie
collection PubMed
description Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by barrier dysfunction, dysregulated immune response, and dysbiosis with increased Staphylococcus aureus colonization. Infiltration of various T helper cell subsets into lesional skin and subsequent cytokine release are a hallmark of AD. Release of cytokines by both T cells and keratinocytes plays a key role in skin inflammation and drives many AD features. This review aims to discuss cytokine-mediated crosstalk between T cells and keratinocytes in AD pathogenesis and the potential impact of virulence factors produced by Staphylococcus aureus on these interactions.
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spelling pubmed-90227452022-04-22 Cytokine-Mediated Crosstalk Between Keratinocytes and T Cells in Atopic Dermatitis Humeau, Mélanie Boniface, Katia Bodet, Charles Front Immunol Immunology Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by barrier dysfunction, dysregulated immune response, and dysbiosis with increased Staphylococcus aureus colonization. Infiltration of various T helper cell subsets into lesional skin and subsequent cytokine release are a hallmark of AD. Release of cytokines by both T cells and keratinocytes plays a key role in skin inflammation and drives many AD features. This review aims to discuss cytokine-mediated crosstalk between T cells and keratinocytes in AD pathogenesis and the potential impact of virulence factors produced by Staphylococcus aureus on these interactions. Frontiers Media S.A. 2022-04-07 /pmc/articles/PMC9022745/ /pubmed/35464457 http://dx.doi.org/10.3389/fimmu.2022.801579 Text en Copyright © 2022 Humeau, Boniface and Bodet https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Humeau, Mélanie
Boniface, Katia
Bodet, Charles
Cytokine-Mediated Crosstalk Between Keratinocytes and T Cells in Atopic Dermatitis
title Cytokine-Mediated Crosstalk Between Keratinocytes and T Cells in Atopic Dermatitis
title_full Cytokine-Mediated Crosstalk Between Keratinocytes and T Cells in Atopic Dermatitis
title_fullStr Cytokine-Mediated Crosstalk Between Keratinocytes and T Cells in Atopic Dermatitis
title_full_unstemmed Cytokine-Mediated Crosstalk Between Keratinocytes and T Cells in Atopic Dermatitis
title_short Cytokine-Mediated Crosstalk Between Keratinocytes and T Cells in Atopic Dermatitis
title_sort cytokine-mediated crosstalk between keratinocytes and t cells in atopic dermatitis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022745/
https://www.ncbi.nlm.nih.gov/pubmed/35464457
http://dx.doi.org/10.3389/fimmu.2022.801579
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