Cargando…

Overcoming the Challenges Imposed by Humoral Immunity to AAV Vectors to Achieve Safe and Efficient Gene Transfer in Seropositive Patients

One of the major goals of in vivo gene transfer is to achieve long-term expression of therapeutic transgenes in terminally differentiated cells. The extensive clinical experience and the recent approval of Luxturna(®) (Spark Therapeutics, now Roche) and Zolgensma(®) (AveXis, now Novartis) place vect...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gross, David-Alexandre, Tedesco, Novella, Leborgne, Christian, Ronzitti, Giuseppe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022790/ https://www.ncbi.nlm.nih.gov/pubmed/35464422 http://dx.doi.org/10.3389/fimmu.2022.857276

Ejemplares similares

Human Immune Responses to Adeno-Associated Virus (AAV) Vectors
por: Ronzitti, Giuseppe, et al.
Publicado: (2020)

A translationally optimized AAV-UGT1A1 vector drives safe and long-lasting correction of Crigler-Najjar syndrome
por: Ronzitti, Giuseppe, et al.
Publicado: (2016)

Influence of Pre-existing Anti-capsid Neutralizing and Binding Antibodies on AAV Vector Transduction
por: Fitzpatrick, Zachary, et al.
Publicado: (2018)

Prevalence and pharmacological modulation of humoral immunity to AAV vectors in gene transfer to synovial tissue
por: Mingozzi, F, et al.
Publicado: (2013)

A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear
por: Landegger, Lukas D., et al.
Publicado: (2017)

AAV-ie enables safe and efficient gene transfer to inner ear cells
por: Tan, Fangzhi, et al.
Publicado: (2019)

Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration
por: Meliani, Amine, et al.
Publicado: (2018)

Humoral Immune Response to AAV
por: Calcedo, Roberto, et al.
Publicado: (2013)

Triple Vectors Expand AAV Transfer Capacity in the Retina
por: Maddalena, Andrea, et al.
Publicado: (2018)

Ultrafiltered recombinant AAV8 vector can be safely administered in vivo and efficiently transduces liver
por: Kleven, Mark D., et al.
Publicado: (2018)

Overcoming Barriers to Preventing and Treating P. aeruginosa Infections Using AAV Vectored Immunoprophylaxis
por: Lopes, Jordyn A., et al.
Publicado: (2022)

Semirational bioengineering of AAV vectors with increased potency and specificity for systemic gene therapy of muscle disorders
por: El Andari, Jihad, et al.
Publicado: (2022)

Emerging Issues in AAV-Mediated In Vivo Gene Therapy
por: Colella, Pasqualina, et al.
Publicado: (2017)

Intraocular route of AAV2 vector administration defines humoral immune response and therapeutic potential
por: Li, Qiuhong, et al.
Publicado: (2008)

Efficacious, safe, and stable inhibition of corneal neovascularization by AAV-vectored anti-VEGF therapeutics
por: Su, Wenqi, et al.
Publicado: (2021)

Rationale and strategies for the development of safe and effective optimized AAV vectors for human gene therapy
por: Srivastava, Arun
Publicado: (2023)

Immunogenicity of Recombinant Adeno-Associated Virus (AAV) Vectors for Gene Transfer
por: Arjomandnejad, Motahareh, et al.
Publicado: (2023)

Transcriptional Targeting Approaches in Cardiac Gene Transfer Using AAV Vectors
por: Schröder, Lena C., et al.
Publicado: (2023)

Development of a dual hybrid AAV vector for endothelial-targeted expression of von Willebrand factor
por: Barbon, Elena, et al.
Publicado: (2021)

T Cell-Mediated Immune Responses to AAV and AAV Vectors
por: Ertl, Hildegund C. J.
Publicado: (2021)

A versatile toolkit for overcoming AAV immunity
por: Li, Xuefeng, et al.
Publicado: (2022)

Pharmacological Modulation of Humoral Immunity in a Nonhuman Primate Model of AAV Gene Transfer for Hemophilia B
por: Mingozzi, Federico, et al.
Publicado: (2012)

rAAV Vectors as Safe and Efficient Tools for the Stable Delivery of Genes to Primary Human Chondrosarcoma Cells In Vitro and In Situ
por: Madry, Henning, et al.
Publicado: (2012)

Characterization of Naturally-Occurring Humoral Immunity to AAV in Sheep
por: Tellez, Joseph, et al.
Publicado: (2013)

AAV-8 and AAV-9 Vectors Cooperate with Serum Proteins Differently Than AAV-1 and AAV-6
por: Denard, Jérôme, et al.
Publicado: (2018)

Lethal Consequences of Overcoming Metabolic Restrictions Imposed on a Cooperative Bacterial Population
por: Goo, Eunhye, et al.
Publicado: (2017)

A concept of eliminating nonhomologous recombination for scalable and safe AAV vector generation for human gene therapy
por: Dong, Biao, et al.
Publicado: (2013)

Liver-Directed but Not Muscle-Directed AAV-Antibody Gene Transfer Limits Humoral Immune Responses in Rhesus Monkeys
por: Fuchs, Sebastian P., et al.
Publicado: (2019)

Lack of Humoral Immune Response to the Tetracycline (Tet) Activator in Rats Injected Intracranially with Tet-off rAAV Vectors
por: Han, Ye, et al.
Publicado: (2010)

Pre-existing humoral immunity and complement pathway contribute to immunogenicity of adeno-associated virus (AAV) vector in human blood
por: Smith, Corinne J., et al.
Publicado: (2022)

Syngeneic AAV Pseudo-particles Potentiate Gene Transduction of AAV Vectors
por: Wang, Qizhao, et al.
Publicado: (2016)

Efficacy, pharmacokinetics, and safety in the mouse and primate retina of dual AAV vectors for Usher syndrome type 1B
por: Ferla, Rita, et al.
Publicado: (2023)

Polymers for Improving the In Vivo Transduction Efficiency of AAV2 Vectors
por: Moulay, Gilles, et al.
Publicado: (2010)

Selection of an Efficient AAV Vector for Robust CNS Transgene Expression
por: Hanlon, Killian S., et al.
Publicado: (2019)

Adapting to survive: How Candida overcomes host-imposed constraints during human colonization
por: Alves, Rosana, et al.
Publicado: (2020)

Innate Immune Responses to AAV Vectors
por: Rogers, Geoffrey L., et al.
Publicado: (2011)

AAV Vectored Immunoprophylaxis for Filovirus Infections
por: Rghei, Amira D., et al.
Publicado: (2020)

AAV gene therapy vectors in the TMJ
por: Brouxhon, Sabine M., et al.
Publicado: (2022)

Targeting the somatosensory system with AAV9 and AAV2retro viral vectors
por: Skorput, Alexander G. J., et al.
Publicado: (2022)

Transcriptional activity of novel ALDH1L1 promoters in the rat brain following AAV vector-mediated gene transfer
por: Mudannayake, Janitha M, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_9deakvch2klsar24ulnr6iujhr