Tumor suppressor PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7/autophagy to suppress neurodegeneration

The PALB2 tumor suppressor plays key roles in DNA repair and has been implicated in redox homeostasis. Autophagy maintains mitochondrial quality, mitigates oxidative stress and suppresses neurodegeneration. Here we show that Palb2 deletion in the mouse brain leads to mild motor deficits and that co-...

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Detalles Bibliográficos
Autores principales: Huo, Yanying, Sawant, Akshada, Tan, Yongmei, Mahdi, Amar H, Li, Tao, Ma, Hui, Bhatt, Vrushank, Yan, Run, Coleman, Jake, Dreyfus, Cheryl F, Guo, Jessie Yanxiang, Mouradian, M. Maral, White, Eileen, Xia, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022806/
https://www.ncbi.nlm.nih.gov/pubmed/35404932
http://dx.doi.org/10.1371/journal.pgen.1010138

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