The mTOR inhibitor Rapamycin protects from premature cellular senescence early after experimental kidney transplantation

Interstitial fibrosis and tubular atrophy, a major cause of kidney allograft dysfunction, has been linked to premature cellular senescence. The mTOR inhibitor Rapamycin protects from senescence in experimental models, but its antiproliferative properties have raised concern early after transplantati...

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Detalles Bibliográficos
Autores principales: Hoff, Uwe, Markmann, Denise, Thurn-Valassina, Daniela, Nieminen-Kelhä, Melina, Erlangga, Zulrahman, Schmitz, Jessica, Bräsen, Jan Hinrich, Budde, Klemens, Melk, Anette, Hegner, Björn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022825/
https://www.ncbi.nlm.nih.gov/pubmed/35446876
http://dx.doi.org/10.1371/journal.pone.0266319

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