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Evaluation of maternal-infant dyad inflammatory cytokines in pregnancies affected by maternal SARS-CoV-2 infection in early and late gestation

OBJECTIVE: SARS-CoV-2 infection induces significant inflammatory cytokine production in adults, but infant cytokine signatures in pregnancies affected by maternal SARS-CoV-2 are less well characterized. We aimed to evaluate cytokine profiles of mothers and their infants following COVID-19 in pregnan...

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Autores principales: Taglauer, Elizabeth S., Dhole, Yashoda, Boateng, Jeffery, Snyder-Cappione, Jennifer, Parker, Samantha E., Clarke, Katherine, Juttukonda, Lillian, Devera, Jean, Hunnewell, Jessica, Barnett, Elizabeth, Jia, Hongpeng, Yarrington, Christina, Sabharwal, Vishakha, Wachman, Elisha M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022897/
https://www.ncbi.nlm.nih.gov/pubmed/35449446
http://dx.doi.org/10.1038/s41372-022-01391-9
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author Taglauer, Elizabeth S.
Dhole, Yashoda
Boateng, Jeffery
Snyder-Cappione, Jennifer
Parker, Samantha E.
Clarke, Katherine
Juttukonda, Lillian
Devera, Jean
Hunnewell, Jessica
Barnett, Elizabeth
Jia, Hongpeng
Yarrington, Christina
Sabharwal, Vishakha
Wachman, Elisha M.
author_facet Taglauer, Elizabeth S.
Dhole, Yashoda
Boateng, Jeffery
Snyder-Cappione, Jennifer
Parker, Samantha E.
Clarke, Katherine
Juttukonda, Lillian
Devera, Jean
Hunnewell, Jessica
Barnett, Elizabeth
Jia, Hongpeng
Yarrington, Christina
Sabharwal, Vishakha
Wachman, Elisha M.
author_sort Taglauer, Elizabeth S.
collection PubMed
description OBJECTIVE: SARS-CoV-2 infection induces significant inflammatory cytokine production in adults, but infant cytokine signatures in pregnancies affected by maternal SARS-CoV-2 are less well characterized. We aimed to evaluate cytokine profiles of mothers and their infants following COVID-19 in pregnancy. STUDY DESIGN: Serum samples at delivery from 31 mother-infant dyads with maternal SARS-CoV-2 infection in pregnancy (COVID) were examined in comparison to 29 control dyads (Control). Samples were evaluated using a 13-plex cytokine assay. RESULTS: In comparison with controls, interleukin (IL)-6 and interferon gamma-induced protein 10 (IP-10) were higher in COVID maternal and infant samples (p < 0.05) and IL-8 uniquely elevated in COVID infant samples (p < 0.05). Significant elevations in IL-6, IP-10, and IL-8 were found among both early (1st/2nd Trimester) and late (3rd Trimester) maternal SARS-CoV-2 infections. CONCLUSIONS: Maternal SARS-CoV-2 infections throughout gestation are associated with increased maternal and infant inflammatory cytokines at birth with potential to impact long-term infant health.
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spelling pubmed-90228972022-04-22 Evaluation of maternal-infant dyad inflammatory cytokines in pregnancies affected by maternal SARS-CoV-2 infection in early and late gestation Taglauer, Elizabeth S. Dhole, Yashoda Boateng, Jeffery Snyder-Cappione, Jennifer Parker, Samantha E. Clarke, Katherine Juttukonda, Lillian Devera, Jean Hunnewell, Jessica Barnett, Elizabeth Jia, Hongpeng Yarrington, Christina Sabharwal, Vishakha Wachman, Elisha M. J Perinatol Article OBJECTIVE: SARS-CoV-2 infection induces significant inflammatory cytokine production in adults, but infant cytokine signatures in pregnancies affected by maternal SARS-CoV-2 are less well characterized. We aimed to evaluate cytokine profiles of mothers and their infants following COVID-19 in pregnancy. STUDY DESIGN: Serum samples at delivery from 31 mother-infant dyads with maternal SARS-CoV-2 infection in pregnancy (COVID) were examined in comparison to 29 control dyads (Control). Samples were evaluated using a 13-plex cytokine assay. RESULTS: In comparison with controls, interleukin (IL)-6 and interferon gamma-induced protein 10 (IP-10) were higher in COVID maternal and infant samples (p < 0.05) and IL-8 uniquely elevated in COVID infant samples (p < 0.05). Significant elevations in IL-6, IP-10, and IL-8 were found among both early (1st/2nd Trimester) and late (3rd Trimester) maternal SARS-CoV-2 infections. CONCLUSIONS: Maternal SARS-CoV-2 infections throughout gestation are associated with increased maternal and infant inflammatory cytokines at birth with potential to impact long-term infant health. Nature Publishing Group US 2022-04-21 2022 /pmc/articles/PMC9022897/ /pubmed/35449446 http://dx.doi.org/10.1038/s41372-022-01391-9 Text en © The Author(s), under exclusive licence to Springer Nature America, Inc. 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Taglauer, Elizabeth S.
Dhole, Yashoda
Boateng, Jeffery
Snyder-Cappione, Jennifer
Parker, Samantha E.
Clarke, Katherine
Juttukonda, Lillian
Devera, Jean
Hunnewell, Jessica
Barnett, Elizabeth
Jia, Hongpeng
Yarrington, Christina
Sabharwal, Vishakha
Wachman, Elisha M.
Evaluation of maternal-infant dyad inflammatory cytokines in pregnancies affected by maternal SARS-CoV-2 infection in early and late gestation
title Evaluation of maternal-infant dyad inflammatory cytokines in pregnancies affected by maternal SARS-CoV-2 infection in early and late gestation
title_full Evaluation of maternal-infant dyad inflammatory cytokines in pregnancies affected by maternal SARS-CoV-2 infection in early and late gestation
title_fullStr Evaluation of maternal-infant dyad inflammatory cytokines in pregnancies affected by maternal SARS-CoV-2 infection in early and late gestation
title_full_unstemmed Evaluation of maternal-infant dyad inflammatory cytokines in pregnancies affected by maternal SARS-CoV-2 infection in early and late gestation
title_short Evaluation of maternal-infant dyad inflammatory cytokines in pregnancies affected by maternal SARS-CoV-2 infection in early and late gestation
title_sort evaluation of maternal-infant dyad inflammatory cytokines in pregnancies affected by maternal sars-cov-2 infection in early and late gestation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022897/
https://www.ncbi.nlm.nih.gov/pubmed/35449446
http://dx.doi.org/10.1038/s41372-022-01391-9
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