Deletion of Slc6a14 reduces cancer growth and metastatic spread and improves survival in KPC mouse model of spontaneous pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is lethal. There is a dire need for better therapeutic targets. Cancer cells have increased demand for sugars, amino acids, and lipids and therefore up-regulate various nutrient transporters to meet this demand. In PDAC, SLC6A14 (an amino acid transporter (AAT...

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Detalles Bibliográficos
Autores principales: Schniers, Bradley K., Wachtel, Mitchell S., Sharma, Meenu, Korac, Ksenija, Rajasekaran, Devaraja, Yang, Shengping, Sniegowski, Tyler, Ganapathy, Vadivel, Bhutia, Yangzom D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2022
Materias:
Cancer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022989/
https://www.ncbi.nlm.nih.gov/pubmed/35212370
http://dx.doi.org/10.1042/BCJ20210855

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022989/
https://www.ncbi.nlm.nih.gov/pubmed/35212370
http://dx.doi.org/10.1042/BCJ20210855

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