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Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase

The BTB-Kelch protein KLHL3 is a Cullin3-dependent E3 ligase that mediates the ubiquitin-dependent degradation of kinases WNK1–4 to control blood pressure and cell volume. A crystal structure of KLHL3 has defined its binding to an acidic degron motif containing a PXXP sequence that is strictly conse...

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Detalles Bibliográficos
Autores principales:	Chen, Zhuoyao, Zhang, Jinwei, Murillo-de-Ozores, Adrián R., Castañeda-Bueno, María, D'Amico, Francesca, Heilig, Raphael, Manning, Charlotte E., Sorrell, Fiona J., D'Angiolella, Vincenzo, Fischer, Roman, Mulder, Monique P. C., Gamba, Gerardo, Alessi, Dario R., Bullock, Alex N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2022
Materias:	Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022995/ https://www.ncbi.nlm.nih.gov/pubmed/35179207 http://dx.doi.org/10.1042/BCJ20220019

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