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LMAN1–MCFD2 complex is a cargo receptor for the ER-Golgi transport of α1-antitrypsin

α1-antitrypsin (AAT) is a serine protease inhibitor synthesized in hepatocytes and protects the lung from damage by neutrophil elastase. AAT gene mutations result in AAT deficiency (AATD), which leads to lung and liver diseases. The AAT Z variant forms polymer within the endoplasmic reticulum (ER) o...

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Detalles Bibliográficos
Autores principales:	Zhang, Yuan, Zhu, Min, Zheng, Chunlei, Wei, Wei, Emmer, Brian T., Zhang, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2022
Materias:	Cell Membranes, Excitation & Transport
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9022998/ https://www.ncbi.nlm.nih.gov/pubmed/35322856 http://dx.doi.org/10.1042/BCJ20220055

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