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Cellular Reprogramming and Its Potential Application in Alzheimer’s Disease

Alzheimer’s disease (AD) has become the most common age-related dementia in the world and is currently incurable. Although many efforts have been made, the underlying mechanisms of AD remain unclear. Extracellular amyloid-beta deposition, intracellular tau hyperphosphorylation, neuronal death, glial...

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Autores principales: Zhou, Chao, Ni, Wanyan, Zhu, Taiyang, Dong, Shuyu, Sun, Ping, Hua, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023048/
https://www.ncbi.nlm.nih.gov/pubmed/35464309
http://dx.doi.org/10.3389/fnins.2022.884667
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author Zhou, Chao
Ni, Wanyan
Zhu, Taiyang
Dong, Shuyu
Sun, Ping
Hua, Fang
author_facet Zhou, Chao
Ni, Wanyan
Zhu, Taiyang
Dong, Shuyu
Sun, Ping
Hua, Fang
author_sort Zhou, Chao
collection PubMed
description Alzheimer’s disease (AD) has become the most common age-related dementia in the world and is currently incurable. Although many efforts have been made, the underlying mechanisms of AD remain unclear. Extracellular amyloid-beta deposition, intracellular tau hyperphosphorylation, neuronal death, glial cell activation, white matter damage, blood–brain barrier disruption, and other mechanisms all take part in this complicated disease, making it difficult to find an effective therapy. In the study of therapeutic methods, how to restore functional neurons and integrate myelin becomes the main point. In recent years, with the improvement and maturity of induced pluripotent stem cell technology and direct cell reprogramming technology, it has become possible to induce non-neuronal cells, such as fibroblasts or glial cells, directly into neuronal cells in vitro and in vivo. Remarkably, the induced neurons are functional and capable of entering the local neural net. These encouraging results provide a potential new approach for AD therapy. In this review, we summarized the characteristics of AD, the reprogramming technique, and the current research on the application of cellular reprogramming in AD. The existing problems regarding cellular reprogramming and its therapeutic potential for AD were also reviewed.
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spelling pubmed-90230482022-04-22 Cellular Reprogramming and Its Potential Application in Alzheimer’s Disease Zhou, Chao Ni, Wanyan Zhu, Taiyang Dong, Shuyu Sun, Ping Hua, Fang Front Neurosci Neuroscience Alzheimer’s disease (AD) has become the most common age-related dementia in the world and is currently incurable. Although many efforts have been made, the underlying mechanisms of AD remain unclear. Extracellular amyloid-beta deposition, intracellular tau hyperphosphorylation, neuronal death, glial cell activation, white matter damage, blood–brain barrier disruption, and other mechanisms all take part in this complicated disease, making it difficult to find an effective therapy. In the study of therapeutic methods, how to restore functional neurons and integrate myelin becomes the main point. In recent years, with the improvement and maturity of induced pluripotent stem cell technology and direct cell reprogramming technology, it has become possible to induce non-neuronal cells, such as fibroblasts or glial cells, directly into neuronal cells in vitro and in vivo. Remarkably, the induced neurons are functional and capable of entering the local neural net. These encouraging results provide a potential new approach for AD therapy. In this review, we summarized the characteristics of AD, the reprogramming technique, and the current research on the application of cellular reprogramming in AD. The existing problems regarding cellular reprogramming and its therapeutic potential for AD were also reviewed. Frontiers Media S.A. 2022-04-07 /pmc/articles/PMC9023048/ /pubmed/35464309 http://dx.doi.org/10.3389/fnins.2022.884667 Text en Copyright © 2022 Zhou, Ni, Zhu, Dong, Sun and Hua. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zhou, Chao
Ni, Wanyan
Zhu, Taiyang
Dong, Shuyu
Sun, Ping
Hua, Fang
Cellular Reprogramming and Its Potential Application in Alzheimer’s Disease
title Cellular Reprogramming and Its Potential Application in Alzheimer’s Disease
title_full Cellular Reprogramming and Its Potential Application in Alzheimer’s Disease
title_fullStr Cellular Reprogramming and Its Potential Application in Alzheimer’s Disease
title_full_unstemmed Cellular Reprogramming and Its Potential Application in Alzheimer’s Disease
title_short Cellular Reprogramming and Its Potential Application in Alzheimer’s Disease
title_sort cellular reprogramming and its potential application in alzheimer’s disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023048/
https://www.ncbi.nlm.nih.gov/pubmed/35464309
http://dx.doi.org/10.3389/fnins.2022.884667
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